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873080-25-2

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873080-25-2 Structure

873080-25-2 Structure
IdentificationBack Directory
[Name]

4-Pyrimidinecarboxamide, 5-chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-
[CAS]

873080-25-2
[Synonyms]

ZAP 180013
4-Pyrimidinecarboxamide, 5-chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-
Inhibitor,autoimmune,ZAP-70,tyrosine,T-cell,ZAP 180013,ZAP180013,Tyrosinase,ZAP-180013,antigen,inhibit
[Molecular Formula]

C19H17Cl2N3O4S
[MDL Number]

MFCD07360519
[MOL File]

873080-25-2.mol
[Molecular Weight]

454.33
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

ZAP-180013 is a zeta-chain-associated protein kinase 70 (ZAP-70) inhibitor with an IC50 of 1.8 μM. ZAP-180013 inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs)[1].
[storage]

Store at -20°C
[References]

[1] Patrick R Visperas, et al. Identification of Inhibitors of the Association of ZAP-70 With the T Cell Receptor by High-Throughput Screen. SLAS Discov. 2017 Mar;22(3):324-331. DOI:10.1177/1087057116681407
Spectrum DetailBack Directory
[Spectrum Detail]

4-Pyrimidinecarboxamide, 5-chloro-N-[(4-chlorophenyl)methyl]-2-(ethylsulfonyl)-N-(2-furanylmethyl)-(873080-25-2)1HNMR
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