| Identification | Back Directory | [Name]
L-ARGININE T-BUTYL ESTER DIHYDROCHLORIDE | [CAS]
87459-72-1 | [Synonyms]
H-Arg-OtbuHcl
L-Arg-OEt·HCl
L-Arg-OtBu·2HCl
H-Arg-OtBu.2HCI
H-L-Arg-OtBu*2HCl
H-Arg-OtBu dihydrochloride
H-L-Arg-OtBu Dihydrochloride
L-Arginine 1,1-dimethylethyl ester dihydrochloride
L-ARGININE T-BUTYL ESTER DIHYDROCHLORIDE USP/EP/BP
L-Arginine-tert-butyl ester dihydrochloride≥ 98% (TLC)
1,1-dimethylethyl ester-L-Arginine, hydrochloride (1:2)
L-Arginine,1,1-diMethylethyl ester, hydrochloride (1:2)
(S)-tert-butyl 2-amino-5-guanidinopentanoate hydrochloride
tert-butyl (2R)-2-amino-5-carbamimidamidopentanoate hydrochloride
tert-butyl (2S)-2-amino-5-(diaminomethylideneamino)pentanoate,dihydrochloride | [Molecular Formula]
C10H22N4O2.2HCl | [MDL Number]
MFCD08272286 | [MOL File]
87459-72-1.mol | [Molecular Weight]
303.3 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white solid | [Uses]
H-Arg-OtBu (dihydrochloride) is a membrane-targeting antimicrobial. H-Arg-OtBu (dihydrochloride) targets the negatively charged bacterial membrane via a combination of electrostatic and hydrophobic interactions. H-Arg-OtBu (dihydrochloride) can be used for bacterial infections diseases research[1]. | [in vivo]
H-Arg-OtBu (dihydrochloride) (0.3% solutions treated for 3 times per day) has no signs of corneal inflammation and no evidence of an inflammatory response in rabbit corneal wound healing model[1].
H-Arg-OtBu (dihydrochloride) (0.3% solutions treated for 5 times per day) is effective in a mouse model of corneal infection by S. aureus and MRSA[1].
| [References]
[1] Koh JJ, et al, Beuerman RW. Amino acid modified xanthone derivatives: novel, highly promising membrane-active antimicrobials for multidrug-resistant Gram-positive bacterial infections. J Med Chem. 2015 Jan 22;58(2):739-52. DOI:10.1021/jm501285x |
|
|