| Identification | Back Directory | [Name]
BOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID | [CAS]
882847-13-4 | [Synonyms]
Boc-NH-PEG6-COOH
Boc-N-amido-PEG6-acid
Boc-NH-PEG6-CH2CH2COOH
t-Boc-N-amido-PEG6-acid
t-Boc-N-amido-PEG7-acid
T-BOC-NH-AMIDO-PEG6-COOH
Boc-NH-(PEG)-COOH (22 atoms)
t-boc-N-amido-PEG6-propionic acid
Boc-NH-(PEG)-COOH (22 atoms) Novabiochem
BOC-21-AMINO-4,7,10,13,16,19-HEXAOXAHENEICOSANOIC ACID
21-(Boc-aMino)-4,7,10,13,16,19-hexaoxaheneicosanoic acid
21-[(tert-Butoxycarbonyl)amino]-4,7,10,13,16,19-hexaoxaheneicosanoic Acid
2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azahexacosan-26-oic Acid
5,8,11,14,17,20-Hexaoxa-2-azatricosanedioic acid 1-(1,1-dimethylethyl) ester | [Molecular Formula]
C20H39NO10 | [MDL Number]
MFCD07781255 | [MOL File]
882847-13-4.mol | [Molecular Weight]
453.52 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
clear liquid | [color ]
Colorless to Light yellow to Light orange | [Major Application]
peptide synthesis | [InChI]
InChI=1S/C20H39NO10/c1-20(2,3)31-19(24)21-5-7-26-9-11-28-13-15-30-17-16-29-14-12-27-10-8-25-6-4-18(22)23/h4-17H2,1-3H3,(H,21,24)(H,22,23) | [InChIKey]
FTTYOIHYERRXQB-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)NCCOCCOCCOCCOCCOCCOCCC(O)=O |
| Hazard Information | Back Directory | [Description]
t-Boc-N-amido-PEG6-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Chemical Properties]
Yellow liquid | [Uses]
Boc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [reaction suitability]
reaction type: Pegylations
reagent type: cross-linking reagent | [IC 50]
Cleavable Linker; Alkyl/ether; PEGs | [References]
[1] Michael J. Mcpherson, et al. Glucocorticoid receptor agonist and immunoconjugates thereof. WO2017210471A1. |
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