| Identification | Back Directory | [Name]
Boc-9-AMino-4,7-Dioxanonanoic acid | [CAS]
1347750-75-7 | [Synonyms]
Boc-PEG3- CH2 CH2COOH
Boc-N-amido-PEG3-acid
Boc-NH-PEG3-CH2CH2COOH
t-Boc-N-amido-PEG3-acid
T-BOC-NH-AMIDO-PEG3-COOH
t-boc-N-amido-PEG3-propionic acid
Boc-9-AMino-4,7-Dioxanonanoic acid
(Boc-amino)-PEG3-C2-Carboxylic Acid
12-(Boc-amino)-4,7,10-trioxadodecanoic Acid
12-[(tert-Butoxycarbonyl)amino]-4,7,10-trioxadodecanoic Acid
2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azaheptadecan-17-oic acid
5,8,11-Trioxa-2-azatetradecanedioic acid 1-(1,1-dimethylethyl) ester | [Molecular Formula]
C12H23NO6 | [MDL Number]
MFCD24539476 | [MOL File]
1347750-75-7.mol | [Molecular Weight]
277.314 |
| Chemical Properties | Back Directory | [Boiling point ]
471.1±40.0 °C(Predicted) | [density ]
1.124±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Sparingly), Methanol(Sparingly) | [form ]
Oil | [pka]
4.28±0.10(Predicted) | [color ]
Colourless | [InChI]
InChI=1S/C14H27NO7/c1-14(2,3)22-13(18)15-5-7-20-9-11-21-10-8-19-6-4-12(16)17/h4-11H2,1-3H3,(H,15,18)(H,16,17) | [InChIKey]
PFAQEUVPPBOTTA-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)NCCOCCOCCOCCC(O)=O |
| Hazard Information | Back Directory | [Description]
t-Boc-N-amido-PEG3-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Uses]
Boc-N-amido-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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| Company Name: |
Biomatrik Inc. Gold
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0573-82623377 18967387295 |
| Website: |
www.biomatrik.cn |
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T&W GROUP
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021-61551611 13296011611 |
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www.trustwe.com/ |
| Company Name: |
Borenpharm Co., Ltd
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| Telephone: |
027-65563561 18717150066 |
| Website: |
www.borenpharm.com |
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