| Identification | Back Directory | [Name]
5H-BENZO[E]PYRIDO[3,2-B][1,4]DIAZEPIN-6(11H)-ONE | [CAS]
885-70-1 | [Synonyms]
LS 75
Pirenzepine EP Impurity B
11H-Pyrido[2,3-b][1,4]benzodiazepine-6(5H)-one
5H-BENZO[E]PYRIDO[3,2-B][1,4]DIAZEPIN-6(11H)-ONE
5,11-dihydropyrido[2,3-b][1,4]benzodiazepin-6-one
1,5-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 1,5-dihydro-
6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one,5,11-dihydro-
5,6-Dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine
5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one AK-36728 | [EINECS(EC#)]
212-944-2 | [Molecular Formula]
C12H9N3O | [MDL Number]
MFCD00190169 | [MOL File]
885-70-1.mol | [Molecular Weight]
211.22 |
| Chemical Properties | Back Directory | [Melting point ]
292-293℃ | [Boiling point ]
336℃ | [density ]
1.275 | [Fp ]
157℃ | [storage temp. ]
Refrigerator, under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [pka]
11.58±0.20(Predicted) | [color ]
Light Beige to Beige |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow crystals. Melting point 283-285℃ (286-288℃). | [Uses]
5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one, can be used in the synthesis of fluorescent pirenzepine derivatives, used as potential bitopic ligands of the Human M1 Muscarinic receptor. | [Synthesis]
In a 1000 ml reaction flask,Add 600 ml of butanol,100 g of 2-amino-N- (2-chloropyridyl-3-yl) benzamide,2 ml of concentrated sulfuric acid,The reaction was refluxed for 3 hours at a reaction temperature of 80 ?? C,Cooled to room temperature,filter,Washed with acetone,50-60 ?? C in vacuo to give 98 g of a pale yellow solid product,Yield 98percent, purity 99percent. | [References]
[1] Patent: CN106432227, 2017, A. Location in patent: Paragraph 0019; 0020
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 17, p. 4300 - 4315
[3] Journal of Medicinal Chemistry, 1993, vol. 36, # 15, p. 2107 - 2114
[4] Collection of Czechoslovak Chemical Communications, 1988, vol. 53, # 8, p. 1820 - 1844
[5] Patent: WO2006/8118, 2006, A1. Location in patent: Page/Page column 20 |
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