| Identification | Back Directory | [Name]
(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol | [CAS]
88930-15-8 | [Synonyms]
Mogrol
Mogrol, >98%
(24R)-Cucurbit-5-ene-3β,11α,24,25-tetrol
(10α,24R)-9β-Methyl-19-norlanosta-5-ene-3β,11α,24,25-tetrol
(10α,24R)-3β,11α,24,25-Tetrahydroxy-9β-methyl-19-norlanosta-5-ene | [Molecular Formula]
C30H52O4 | [MDL Number]
MFCD29904541 | [MOL File]
88930-15-8.mol | [Molecular Weight]
476.73 |
| Chemical Properties | Back Directory | [Boiling point ]
595.6±50.0 °C(Predicted) | [density ]
1.10±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.67±0.29(Predicted) | [color ]
White to off-white | [InChIKey]
JLYBBRAAICDTIS-AYEHCKLZSA-N | [CAS DataBase Reference]
88930-15-8 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Momordica grosvenori. | [Uses]
Mogrol is a biometabolite of mogrosides, and acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling. | [Definition]
ChEBI: Mogrol is a tetracyclic triterpenoid that is cucurbitadienol in which the side-chain double bond (position 24-25) has undergone formal oxidation to introduce hydroxy groups at positions 24 and 25 (the 24R stereoisomer). It is a biometabolite of mogrosides found in Siraitia grosvenorii. It has a role as an antineoplastic agent. It is a tetracyclic triterpenoid and a hydroxy seco-steroid. It is functionally related to a cucurbitadienol. | [Biochem/physiol Actions]
Mogrol is an aglycone of mogrosides from Siraitia grosvenorii that exhibits neuroprotective and anticancer activities. It induces apoptosis in K562 leukemia cells through suppression of ERK1/2 and STAT3 pathways. Mogrol appears to ameliorate the memory impairment caused by Aβ1-42 in mice. Mogrol increases AMPK activity in hepatocytes and suppresses adipocyte differentiation in 3T3-L1 cells. | [Synthesis]
1) Luo Han Guo dried fruit 100g, crushed into very coarse powder, add 600mL 70% industrial ethanol reflux extraction for 3h, filtration, filtrate recovery of ethanol (can be used again for the extraction of herbs), to get the alcohol extract 9.5g. .
2)Tak | [IC 50]
ERK1; ERK2; STAT3 | [storage]
Store at -20°C | [References]
[1] Liu C, et al. Mogrol represents a novel leukemia therapeutic, via ERK and STAT3 inhibition. Am J Cancer Res. 2015 Mar 15;5(4):1308-18.
[2] Naoki Harada, et al. Mogrol Derived from Siraitia grosvenorii Mogrosides Suppresses 3T3-L1 Adipocyte Differentiation by Reducing cAMP-Response Element-Binding Protein Phosphorylation and Increasing AMP-Activated Protein Kinase Phosphorylation. PLoS One. 2 |
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