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89211-34-7

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89211-34-7 Structure

89211-34-7 Structure
IdentificationBack Directory
[Name]

3-(2-hydroxyethoxy)propanoic acid
[CAS]

89211-34-7
[Synonyms]

89211-34-7
OH-PEG1-COOH
Hydroxy-PEG1-acid
3-(2-hydroxyethoxy)propanoic acid
Propanoic acid, 3-(2-hydroxyethoxy)-
[Molecular Formula]

C5H10O4
[MDL Number]

MFCD11618155
[MOL File]

89211-34-7.mol
[Molecular Weight]

134.13
Chemical PropertiesBack Directory
[Boiling point ]

127-130 °C(Press: 2 Torr)
[density ]

1.224±0.06 g/cm3(Predicted)
[storage temp. ]

Storage temp. 2-8°C
[form ]

Liquid
[pka]

4.26±0.10(Predicted)
[color ]

Colorless to light yellow
[InChIKey]

GTIFLSYPOXYYFG-UHFFFAOYSA-N
[SMILES]

O=C(O)CCOCCO
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
[Storage Class]

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
[Hazard Classifications]

Acute Tox. 3 Oral
Hazard InformationBack Directory
[Uses]

Hydroxy-PEG1-acid is a non-cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
[IC 50]

Non-cleavable Linker
[References]

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
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