| Identification | More | [Name]
3-Mercaptopropionic acid | [CAS]
107-96-0 | [Synonyms]
3-MERCAPTO PROPIONATE
3-MERCAPTOPROPIONIC ACID
3-MPA
BETA-MERCAPTOPROPIONIC ACID
B-THIOPROPIONIC ACID
β-Mercaptopropionic acid
PROPANOIC ACID, 3-MERCAPTO
PROPONOIC ACID, 3-MERCAPTO
3-Mercaptopropanoic acid
3-mercapto-propanoicaci
3-mercaptopropanoicacid
3-mercapto-Propanoicacid
3-mercaptopropionic
3-mercapto-propionicaci
3-mercpato-propionicaci
3-Sulfanylpropanoic acid
3-Thiopropionic acid
3-thiopropionicacid
acidemercapto-3propionique
beta-mercaptopropanoicacid | [EINECS(EC#)]
203-537-0 | [Molecular Formula]
C3H6O2S | [MDL Number]
MFCD00004897 | [Molecular Weight]
106.14 | [MOL File]
107-96-0.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colourless to yellowish liquid after melting | [Melting point ]
15-18 °C (lit.) | [Boiling point ]
110-111 °C/15 mmHg (lit.) | [density ]
1.218 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.04 mm Hg ( 20 °C)
| [FEMA ]
4587 | 3-MERCAPTOPROPIONIC ACID | [refractive index ]
n20/D 1.492(lit.)
| [Fp ]
201 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder, Crystals, and/or Chunks | [pka]
pK1:;pK2:10.84(SH) (25°C) | [color ]
White | [Specific Gravity]
1.218 | [Odor]
sulfurous roasted | [PH]
2 (120g/l, H2O, 20℃) | [explosive limit]
1.60%(V) | [Odor Type]
sulfurous | [Water Solubility ]
soluble | [Sensitive ]
Air Sensitive & Hygroscopic | [JECFA Number]
1936 | [BRN ]
773807 | [Stability:]
Air Sensitive, Hygroscopic | [Cosmetics Ingredients Functions]
DEPILATORY
HAIR WAVING OR STRAIGHTENING
REDUCING | [InChI]
1S/C3H6O2S/c4-3(5)1-2-6/h6H,1-2H2,(H,4,5) | [InChIKey]
DKIDEFUBRARXTE-UHFFFAOYSA-N | [SMILES]
OC(=O)CCS | [LogP]
-2.3 at 22℃ | [CAS DataBase Reference]
107-96-0(CAS DataBase Reference) | [NIST Chemistry Reference]
3-Thiolpropanoic acid(107-96-0) | [EPA Substance Registry System]
107-96-0(EPA Substance) | [Absorption]
cut-off at 270nm |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS06 | [Signal word ]
Danger | [Hazard statements ]
H290-H301-H314-H332 | [Precautionary statements ]
P234-P261-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | [Hazard Codes ]
T | [Risk Statements ]
R25:Toxic if swallowed.
R34:Causes burns.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S7:Keep container tightly closed .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2922 8/PG 2
| [WGK Germany ]
1
| [RTECS ]
UF5270000
| [F ]
10-13 | [Autoignition Temperature]
662 °F | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29309070 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 3 Oral
Acute Tox. 4 Inhalation
Eye Dam. 1
Met. Corr. 1
Skin Corr. 1B | [Hazardous Substances Data]
107-96-0(Hazardous Substances Data) | [Toxicity]
LD50 orally in Rabbit: 96 mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
clear colourless to yellowish liquid after melting | [Uses]
A compound suitable for amino acid analysis by means of OPA | [Application]
3-Mercaptopropionic acid (3-MPA) is used to produce hydrophilic SAMs, which are terminated with carboxylic acids and can be further functionalized to introduce more complex end groups such as enzymes for biosensor applications. SAMs of 3-MPA are capped on ZnSe quantum dots for the electrochemical detection of dopamine. 3-MPA is used as a capping agent on CdTe quantum dot nanocrystals (QD NCs) for use as labeling materials in biomedical applications. It can also be used to modify the surface of iron oxide nanoparticles (Fe2O3) in the extraction and preconcentration of Al3+ and Cr3+ ions from different biological samples. | [Definition]
ChEBI: A mercaptopropanoic acid that is propanoic acid carrying a sulfanyl group at position 3. | [Reactions]
In organic reactions, 3-Mercaptopropionic acid acts as a sulfide ion equivalent and is utilized in the preparation of diaryl sulfide from aryl iodide. | [General Description]
3-Mercaptopropionic acid (3-MPA) is used as a self-assembled monolayer (SAM) with a thiol and carboxylic groups. It has short carbon chains and is mainly used as a capping agent on a variety of nanoparticles. | [Agricultural Uses]
3-Mercaptopropionic acid (3-MPA) has been identified as a promising natural compound with potential anti-browning properties. 3-MPA treatment enhanced antioxidant capacity, reduced PPO activity, and mitigated quinone formation in potato samples. Molecular docking simulations and dynamics analyses revealed that 3-MPA competitively binds to PPO's active site, forming a stable enzyme-inhibitor complex that effectively blocks substrate access[2]. | [Biological Activity]
3-Mercaptopropionic acid is a blocking drug that causes an increase in sleep and a decrease in wakefulness. A related finding is that nipecotic acid also increases the time needed for isoflurane to induce loss of consciousness, whereas 3-mercaptopropionic acid decreases anesthesia induction time[1].
| [References]
[1] Thakkar, M. and R. McCarley. “Neurochemistry of Sleep and Wakefulness: Histamine in the control of sleep–wakefulness.”Basic Neurochemistry (Eighth Edition) (2012).
|
| Questions And Answer | Back Directory | [Anti-cancer properties]
3-Mercaptopropionic acid is a liquid, and doses between 30 and 60 mg/kg can be used for IP seizure induction throughout development. 3-mercaptopropionic acid (3-MPA) is a convulsant and potent GAD1 inhibitor, which could inhibit the migration and invasiveness of oral cancer cells. Considering that inhibition of GAD1 impaired GABA-mediated immunosuppression, 3-MPA was also demonstrated to synergize with ICB treatment to exert better anti-tumor efficacy. Such a combination strategy could benefit the treatment of cancer types with elevated GAD1 expression. Since 3-MPA has not been approved for clinical use, it is urgent to discover novel GAD1 inhibitors that are more applicable to future clinical studies.
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
|