| Identification | Back Directory | [Name]
LY2334737 | [CAS]
892128-60-8 | [Synonyms]
LY2334737
LY 2334737;LY-2334737;LY2334737
2'-Deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)cytidine
Cytidine, 2'-deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)- | [Molecular Formula]
C17H25F2N3O5 | [MDL Number]
MFCD25976631 | [MOL File]
892128-60-8.mol | [Molecular Weight]
389.39 |
| Hazard Information | Back Directory | [Biological Activity]
ly2334737 is an oral prodrug of gemcitabine, the clinically efficacious anticancer agent [1].ly2334737 has been shown the hydrolytic activity by carboxylesterase 2 (ces2). the michaelis-menten kinetic parameters are exhibited to be : km of 43μm and vmax of 40nmol/min/mg protein. in addition, ly2334737 has been found to be cytotoxic to cells in the ncl-60 panel with the ec50 values of 0.512±0.016μm, 0.402±0.018μm and 0.034±0.002μm for pc-gfp alone, hct-116 mock transfectant and hct-116 ces2 transfectant cell lines, respectively. apart from these, the study result has been noted that parental sk-ov-3 cells were approximately 4-fold more sensitive to ly2334737 cytotoxicity than the sk-ov-3 knockdown with the ec50 values of 1.1μm and 4.5μm, respectively [1]. | [References]
[1] pratt se1, durland-busbice s, shepard rl, heinz-taheny k, iversen pw, dantzig ah. human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (ly2334737) and confers prodrug sensitivity to cancer cells. clin cancer res. 2013 mar 1;19(5):1159-68. |
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| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Website: |
www.spiropharma.com.cn |
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