| Identification | More | [Name]
2,3-Difluoro-5-chloropyridine | [CAS]
89402-43-7 | [Synonyms]
2,3-DIFLUORO-5-CHLOROPYRIDIN
2,3-DIFLUORO-5-CHLOROPYRIDINE
5-CHLORO-2,3-DIFLUOROPYRIDINE
5-Chloro-2,3-Difluoropyridine96%
2,3-Difluoro-5-Chloro
2,3-Difulor-5-Chloropyridine
5-Chloro-2,3-difluoropyridine 98%
5-Chloro-2,3-difluoropyridine98%
5-Chloro-2,3 difluro pyridine | [EINECS(EC#)]
410-090-7 | [Molecular Formula]
C5H2ClF2N | [MDL Number]
MFCD04039314 | [Molecular Weight]
149.53 | [MOL File]
89402-43-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
47-49 C | [Boiling point ]
135°C | [density ]
1,442 g/cm3 | [refractive index ]
1.4738 | [Fp ]
135°C | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Oil | [pka]
-5.14±0.20(Predicted) | [color ]
Clear Colourless | [BRN ]
4177319 | [InChI]
InChI=1S/C5H2ClF2N/c6-3-1-4(7)5(8)9-2-3/h1-2H | [InChIKey]
PERMDYZFNQIKBL-UHFFFAOYSA-N | [SMILES]
C1(F)=NC=C(Cl)C=C1F | [CAS DataBase Reference]
89402-43-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R22:Harmful if swallowed.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S36:Wear suitable protective clothing .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
2810 | [WGK Germany ]
3 | [Hazard Note ]
Harmful | [HazardClass ]
3 | [HazardClass ]
IRRITANT | [PackingGroup ]
III | [HS Code ]
2933399990 |
| Hazard Information | Back Directory | [Uses]
5-Chloro-2,3-difluoropyridine is a 2,3,5-trihalopyridine used in the preparation of the herbicides and pesticides such as chodinafop-propargyl. | [Synthesis]
General procedure for the synthesis of 2,3-difluoro-5-chloropyridine from 2,3,5-trichloropyridine: First, 400 g of cyclobutanesulfone and 400 g of dimethylsulfoxide were added to a 1000 mL flask, and dehydrated to a moisture content of less than 0.05% at 200 °C under 0.05 MPa (negative pressure). Subsequently, 96 g (1.66 mol) of potassium fluoride, 120 g (0.67 mol) of 2,3,5-trichloropyridine, 2 g of 18-crown ether, and 3 g of potassium carbonate were added to the reaction flask at 120 °C and heated to 200 °C for about 3 hours. After completion of the reaction, the product was collected to give 95 g (0.51 mol) of 2,3-difluoro-5-chloropyridine in 90% yield. The purity of the product was 96.8% as determined by gas chromatography. | [References]
[1] Patent: CN106008329, 2016, A. Location in patent: Paragraph 0008; 0009
[2] Synthetic Communications, 2004, vol. 34, # 23, p. 4301 - 4311
[3] Patent: US33478, 1990, E1
[4] Patent: US4565568, 1986, A
[5] Patent: US4678509, 1987, A |
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