| Identification | More | [Name]
2-Cyanoethyl N,N-diisopropylchlorophosphoramidite | [CAS]
89992-70-1 | [Synonyms]
2-CYANOETHYL DIISDPROPYLCHLOROPHOSPHORAMIDITE
2-CYANOETHYL DIISOPROPYLCHLOROPHOSPHORAMIDITE
2-CYANOETHYL N,N-DIISOPROPYLCHLOROPHOSPHORAMIDITE
CHLORO(DIISOPROPYLAMINO)-BETA-CYANOETHOXYPHOSPHINE
CYANOETHYL N,N-DIISOPROPYL PHOSPHOAMIDOCHLORIDITE
2-CYANOETHYL DIISOPROPYLCHLOROPHOSPHORAMIDITE, 14.0%-15.7% CL
2-Cyanoethoxy-N,N'-Diisopropyl Chlorophosphoramidate
Phosphoramidochloridous acid, bis(1-methylethyl)-, 2-cyanoethyl ester
chloro(diisopropylamino)-β-cyanoethoxyphosphine
2-cyanoethyl-N,N-diisopropylchlorophosphoramidite 89992-70-4
3-(chloro(diisopropylamino)phosphinooxy)propanenitrile
3-[Chloro-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
(2-Cyanoethoxy)(diisopropylamino)chlorophosphine
3-(Diisopropylaminochlorophosphinooxy)propiononitrile
3-[Chloro(diisopropylamino)phosphinooxy]propiononitrile
Chloro(2-cyanoethoxy)(diisopropylamino)phosphine
Chloro(diisopropylamino)(2-cyanoethoxy)phosphine
N,N-Diisopropylamidochloridophosphorous acid 2-cyanoethyl ester | [EINECS(EC#)]
628-591-6 | [Molecular Formula]
C9H18ClN2OP | [MDL Number]
MFCD00011544 | [Molecular Weight]
236.68 | [MOL File]
89992-70-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Slightly Hazy Yellow Liquid | [Boiling point ]
103-105°C 0,08mm | [density ]
1.061 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.479
| [Fp ]
>230 °F
| [storage temp. ]
−20°C
| [solubility ]
Miscible with chloroform and dichloromethane. | [form ]
Crystalline Powder | [pka]
0.83±0.70(Predicted) | [color ]
clear to very slightly hazy colorless | [Sensitive ]
Moisture Sensitive | [Usage]
A protecting reagent in DNA synthesis. Also a phosphorylating agent | [BRN ]
3588525 | [Stability:]
Hygroscopic, Moisture Sensitive | [InChI]
InChI=1S/C9H18ClN2OP/c1-8(2)12(9(3)4)14(10)13-7-5-6-11/h8-9H,5,7H2,1-4H3 | [InChIKey]
QWTBDIBOOIAZEF-UHFFFAOYSA-N | [SMILES]
P(N(C(C)C)C(C)C)(Cl)OCCC#N | [CAS DataBase Reference]
89992-70-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS02,GHS05 | [Signal word ]
Danger | [Hazard statements ]
H250-H314 | [Precautionary statements ]
P210-P233-P280-P302+P334-P303+P361+P353-P304+P340+P310-P305+P351+P338-P370+P378 | [Hazard Codes ]
C,T | [Risk Statements ]
R5:Heating may cause an explosion.
R34:Causes burns.
R29:Contact with water liberates toxic gas.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S8:Keep container dry . | [RIDADR ]
UN 2845 4.2/PG 1
| [WGK Germany ]
3
| [F ]
10 | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29299090 |
| Hazard Information | Back Directory | [Chemical Properties]
Slightly Hazy Yellow Liquid | [Uses]
2-Cyanoethyl diisopropylchlorophosphoramidite is a useful intermediate in organic synthesis. It acts as a protecting reagent in DNA synthesis. It is involved in the selective monophosphorylation of carbohydrates and nucleosides. It plays an essential role in the conversion of protected ribonucleosides to phosphoramidites. It is also utilized as phosphitylating reagent for 3'-hydroxyl groups in the synthesis of oligodeoxyribonucleotides. | [Uses]
A protecting reagent in DNA synthesis. Also a phosphorylating agent | [Synthesis]
Under argon protection, N,N-diisopropylethylamine ( 1eq ) was added to a stirred solution of dry 1 -butyl-3 -methylimidazolium bis[ (trifluoromethyl)sulfonylimide] in ionic liquid ( 1 eq ) and PCl3 ( 1 eq ), and then the above mixture was stirred vigorous |
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