| Identification | Back Directory | [Name]
CITRATE SYNTHASE | [CAS]
9027-96-7 | [Synonyms]
CS
-CS
-SP
EC 4.1.3.7
CITRATE SYNTHASE
Synthase, citrate
CITRATE OXALOACETATELYASE
CITRATE CONDENSING ENZYME
CITRATE SYNTHASE USP/EP/BP
Native Pigeon Citrate Synthase
Native Porcine Citrate Synthase
citrate synthase from chicken heart
citrate synthase from porcine heart
CITRATE SYNTHASE FROM PIGEON BREASTMUSCL E
Citrate synthase from E. coli, Recombinant
CITRATE OXALOACETATE LYASE [COA-ACETYLATING
citrate synthase from thermoplasma*acidophilum
Citrate Synthase from porcine heart ammonium sulfate suspension
Citrate condensing enzyme, Citrate oxaloacetate lyase (CoA-acetylating) | [EINECS(EC#)]
232-821-7 | [Molecular Formula]
C6H5O7-3 | [MDL Number]
MFCD00130808 | [MOL File]
9027-96-7.mol | [Molecular Weight]
189.1 |
| Chemical Properties | Back Directory | [Definition]
An enzyme that catalyzes the condensation of
oxaloacetic acid and acetyl-CoA to yield citric acid
and coenzyme A. | [storage temp. ]
2-8°C
| [solubility ]
H2O: soluble1.0mg/mL, clear | [form ]
ammonium sulfate suspension
| [color ]
Colorless to light yellow | [biological source]
Porcine heart | [Water Solubility ]
H2O: soluble 1.0mg/mL, clear | [Specific Activity]
≥100units/mg protein |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
26-36 | [WGK Germany ]
3
| [Toxicity]
A fine powder
used in riot control because of its property of inducing acute
irritation to the eyes, to any skin abrasion and to the tissues of
the respiratory passages, causing coughing and nausea. |
| Hazard Information | Back Directory | [Chemical Properties]
This product is an acidic mucopolysaccharide obtained from animal cartilage tissue. It is an off-white amorphous powder with a slightly salty taste. It is odorless and hygroscopic. The aqueous solution is viscous and does not coagulate upon heating. It is readily soluble in water but insoluble in ethanol, acetone, or glacial acetic acid. The injection is a sterile aqueous solution of chondroitin sulfate sodium salt, a clear, nearly colorless liquid. Chondroitin sulfates are classified according to their chemical composition and structure, including A, B, C, D, E, F, and H. B, F, and H molecules contain L-iduronic acid. B is not degraded by hyaluronidase and develops a different color reaction than A. B is called dermatan sulfate and is more abundant in the skin. Medicinal chondroitin sulfate is extracted from animal cartilage and is primarily a mixture of A, C, and various chondroitin sulfates. It clarifies lipids and enhances the body's detoxification function. It also has diuretic and analgesic properties and is effective for collagen disorders and hearing impairment caused by streptomycin. | [Uses]
Citrate Synthase from porcine heart has been used:
- to inject newt egg for determining its importance in egg activation at fertilization
- in the preparation of reaction mix to determine pyruvate carboxylase enzyme activity
- to examine whether it can induce a [Ca2+]?increase and egg activation in unfertilized eggs
| [Biochem/physiol Actions]
Citrate synthase catalyses the conversion of citrate to acetyl-CoA in the presence of coenzyme-A with the release of H2O and oxaloacetate. The enzyme has a molecular weight of 85 kDa and a pI of 6.1-6.6. It is inhibited by fluoroacetyl-CoA, palmitoyl-CoA, and citroyl-CoA. It is also inhibited when it is acetylated by acetic anhydride or iodinated by iodine. |
|
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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