| Identification | Back Directory | [Name]
6-HYDROXY-3-PYRIDINEBORONIC ACID | [CAS]
903899-13-8 | [Synonyms]
5-BORONO-2-PYRIDONE
2-Hydroxypyridine-5-boronic acid
6-HYDROXY-3-PYRIDINEBORONIC ACID
(6-Hydroxy-3-pyridyl)boronic acid
(6-oxo-1H-pyridin-3-yl)boronic acid
1,6-Dihydro-6-oxopyridine-3-boronic acid
(6-oxo-5,6-dihydropyridin-3-yl)boronic acid
(6-oxo-1,6-dihydropyridin-3-yl)boronic acid
B-(1,6-dihydro-6-oxo-3-pyridinyl)-Boronic acid
Boronic acid, B-(1,6-dihydro-6-oxo-3-pyridinyl)- | [Molecular Formula]
C5H6BNO3 | [MDL Number]
MFCD09907979 | [MOL File]
903899-13-8.mol | [Molecular Weight]
138.92 |
| Chemical Properties | Back Directory | [density ]
1.36±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml,Ethanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
8.02±0.20(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C5H6BNO3/c8-5-2-1-4(3-7-5)6(9)10/h1-3,9-10H,(H,7,8) | [InChIKey]
YUOLAYZNDYRBEZ-UHFFFAOYSA-N | [SMILES]
B(C1C=CC(=O)NC=1)(O)O |
| Hazard Information | Back Directory | [Uses]
6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block, which can be used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B). 6-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors[1][2]. | [References]
[1] Hendricks RT, et al. 3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase. Bioorg Med Chem Lett. 2009 Jan 15;19(2):410-4. DOI:10.1016/j.bmcl.2008.11.060
[2] Verheijen JC, et al. Discovery of 4-morpholino-6-aryl-1H-pyrazolo[3,4-d]pyrimidines as highly potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 6-aryl substituent. J Med Chem. 2009 Dec 24;52(24):8010-24. DOI:10.1021/jm9013828 |
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Energy Chemical
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Tetranov Biopharm
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AllyChem Co., Ltd.
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