| Identification | Back Directory | [Name]
CARBOXYMETHYLCELLULOSE CALCIUM (1.5 G) (AS) | [CAS]
9050-04-8 | [Synonyms]
ecg505
D03400
hylon600
CMCCalcium
calciumcm-cellulose
calciumcelluloseglycolate
Carmellose calcium (jp15)
carboxyMethyl cellose calciuM
Calciam carboxymethylceUulose
CALCIUMCARBOXYLMETHYLCELLULOSE
Carboxymethylcellulose calcium (nf)
Carboxymenthylcellulose Calcium Salt
CarboxyMethyl cellulose, calciuM salt NF
cellulose,carboxymethylether,calciumsalt
CARBOXYMETHYLCELLULOSE CALCIUM (1.5 G) (AS) | [EINECS(EC#)]
618-597-7 | [Molecular Formula]
C23H30ClN3O | [MDL Number]
MFCD00197782 | [MOL File]
9050-04-8.mol | [Molecular Weight]
399.957 |
| Chemical Properties | Back Directory | [solubility ]
Practically insoluble in acetone, chloroform, ethanol
(95%), toluene, and ether. Insoluble in water, but swells to form
a suspension. | [Major Application]
pharmaceutical (small molecule) | [Cosmetics Ingredients Functions]
FILM FORMING
VISCOSITY CONTROLLING
EMULSION STABILISING | [InChI]
InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-14-17(24)9-11-21(19)26-22-12-10-18(28-4)15-20(22)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26) | [InChIKey]
SVUDQUZYHLUPQN-UHFFFAOYSA-N | [SMILES]
Clc1cc2c(nc3c(c2NC(CCCN(CC)CC)C)cc(cc3)OC)cc1 | [EPA Substance Registry System]
Cellulose, carboxymethyl ether, calcium salt (9050-04-8) |
| Hazard Information | Back Directory | [Chemical Properties]
DS 0.5-0.7 | [Uses]
Pharmaceutic aid (tablet
disintegrant). | [Production Methods]
Cellulose, obtained from wood pulp or cotton fibers, is carboxymethylated,
followed by conversion to the calcium salt. It is then
graded on the basis of its degree of carboxymethylation and
pulverized. | [Pharmaceutical Applications]
The main use of carboxymethylcellulose calcium is in tablet
formulations, where it is used as a binder, diluent,
and disintegrant. Although carboxymethylcellulose calcium is
insoluble in water, it is an effective tablet disintegrant as it swells to
several times its original bulk on contact with water. Concentrations
up to 15% w/w may be used in tablet formulations; above this
concentration, tablet hardness is reduced.
Carboxymethylcellulose calcium is also used in other applications
similarly to carboxymethylcellulose sodium; for example, as a
suspending or viscosity-increasing agent in oral and topical
pharmaceutical formulations. Carboxymethylcellulose calcium is
also used in modern wound dressings for its water absorption,
retention and hemostatic properties. | [Safety]
Carboxymethylcellulose calcium is used in oral and topical
pharmaceutical formulations, similarly to carboxymethylcellulose
sodium, and is generally regarded as a nontoxic and nonirritant
material. However, as with other cellulose derivatives, oral
consumption of large amounts of carboxymethylcellulose calcium
may have a laxative effect. | [storage]
Carboxymethylcellulose calcium is a stable, though hygroscopic
material. It should be stored in a well-closed container in a cool, dry
place. | [Regulatory Status]
Included in the FDA Inactive Ingredients Database (oral, capsules
and tablets). Included in nonparenteral medicines licensed in the
UK. Included in the Canadian List of Acceptable Non-medicinal
Ingredients. |
| Safety Data | Back Directory | [WGK Germany ]
WGK 3 | [TSCA ]
TSCA listed | [HS Code ]
3912310000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Resp. Sens. 1
Skin Sens. 1 |
|
| Company Name: |
Spectrum Chemical Manufacturing Corp. Gold
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
AFINE CHEMICALS LIMITED
|
| Telephone: |
+86-571-85134551 +86-18958018566 |
| Website: |
www.afinechem.com/index.html |
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