| Identification | Back Directory | [Name]
3,6,9,12,15,21,24,27,30-Decaoxadotriacontane-1,32-diaMine | [CAS]
928292-69-7 | [Synonyms]
NH2-PEG10-NH2
Amino-PEG10-Amine
H2N-PEG10-CH2CH2NH2
3,6,9,12,15,21,24,27,30-Decaoxadotriacontane-1,32-diaMine
3,6,9,12,15,18,21,24,27,30-Decaoxadotriacontane-1,32-diaMine | [Molecular Formula]
C22H48N2O10 | [MDL Number]
MFCD28122962 | [MOL File]
928292-69-7.mol | [Molecular Weight]
500.62 |
| Chemical Properties | Back Directory | [Boiling point ]
560.0±45.0 °C(Predicted) | [density ]
1.082±0.06 g/cm3(Predicted) | [form ]
Solid-Liquid Mixture | [pka]
9.04±0.10(Predicted) | [color ]
Colorless to off-white |
| Hazard Information | Back Directory | [Description]
Amino-PEG10-Amine is a crosslinking reagent with two amino groups on both sides. The hydrophilic PEG spacer increases solubility in aqueous media. The amino groups are reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. | [Uses]
Amino-PEG10-amine, a PEG-based PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1]. | [IC 50]
PEGs | [References]
[1] Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8(4):707-15. DOI:10.1021/cb3006243 |
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