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90843-31-5

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90843-31-5 Structure

90843-31-5 Structure
IdentificationMore
[Name]

5-ACETYL-2,3-DIHYDROBENZO(B)FURAN
[CAS]

90843-31-5
[Synonyms]

1-(2,3-DIHYDRO-1-BENZOFURAN-5-YL)ETHANONE
1-(2,3-DIHYDROBENZO[B]FURAN-5-YL)ETHAN-1-ONE
5-ACETYL-2,3-DIHYDROBENZO(B)FURAN
5-ACETYL-2,3-DIHYDROBENZOFURAN
BUTTPARK 92\04-30
5-Acetyl-2,3-dihydrobenzo(b)furan,97%
Ethanone, 1-(2,3-dihydro-5-benzofuranyl)-(9CI)
5-acetylcoumaran
5-Acetyl-2,3-dihydrobenzobüfuran, 97%
[Molecular Formula]

C10H10O2
[MDL Number]

MFCD00068033
[Molecular Weight]

162.19
[MOL File]

90843-31-5.mol
Questions And AnswerBack Directory
[Synthesis]

5-Acetyl-2,3-dihydrobenzo(b)furan is prepared from o-bromophenol as the starting material, using water as the solvent, in the presence of the phase-transfer catalyst benzyl-tributyl ammonium chloride, by alkylation with 1,2-dichloroethane, sodium hydroxide and sodium bisulphite under reflux conditions to yield intermediate compound 1. Subsequently, in anhydrous tetrahydrofuran, 1,2-dibromoethane and magnesium are added to carry out an alkylation reaction, thereby yielding 2,3-dihydrobenzofuran (intermediate 2). Finally, acetyl chloride and aluminium trichloride were added to intermediate 2 to carry out the reaction and prepare the final product. The yield reached 76.6%. The reaction route is as follows:

Synthesis of 90843-31-5

Chemical PropertiesBack Directory
[Melting point ]

56-59°C
[Boiling point ]

120-121°C 15mm
[density ]

1.149±0.06 g/cm3(Predicted)
[Fp ]

120-121°C/15mm
[storage temp. ]

Sealed in dry,Room Temperature
[Detection Methods]

GC
[BRN ]

131198
[CAS DataBase Reference]

90843-31-5(CAS DataBase Reference)
[Storage Precautions]

Store under nitrogen
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22-51
[Safety Statements ]

24/25
[HS Code ]

29349990
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Ethyl acetate-->Petroleum ether-->Aluminum chloride-->Acetyl chloride-->2,3-Dihydrobenzofuran-->1-Bromo-2-(2-chloroethoxy)benzene-->2-(2-bromoethyl)phenol-->Acetic anhydride-->2,3-Dihydrofuran-->Chloroacetyl chloride
[Preparation Products]

Benzofuran-5-carboxylic acid-->Darifenacin-->1-(2,3-dihydrobenzofuran-5-yl)ethanamine
Hazard InformationBack Directory
[Chemical Properties]

White to light purple powder
[Uses]

1-(2,3-Dihydro-5-benzofuranyl)ethanone is used to prepare tricyclic [1,2,4]triazine 1,4-dioxides as hypoxia selective cytotoxins. It is also used to synthesize N-(1-benzo[1,3]dioxol-5-yl)ethyl-, N-[1-(2,3-dihydro-benzofuran-5-yl)ethyl-, and N-[1-(2,3-dihydro-1H-indol-5-yl)ethylacrylamides with KCNQ2 opener activities.
Spectrum DetailBack Directory
[Spectrum Detail]

5-ACETYL-2,3-DIHYDROBENZO(B)FURAN(90843-31-5)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

1-(2,3-dihydrobenzo[b]furan-5-yl)ethan-1-one(90843-31-5)
[Alfa Aesar]

5-Acetyl-2,3-dihydrobenzo[b]furan, 97%(90843-31-5)
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