| Identification | Back Directory | [Name]
GGSTOPTM | [CAS]
926281-37-0 | [Synonyms]
GGsTop
GGSTOPTM
GGsTop (Nahlsgen)
GGsTop (Synonyms: Nahlsgen)
3-[[(3-Amino-3-carboxypropyl)methoxyphosphinyl]oxy]benzeneacetic acid
2-Amino-4-((3-(carboxymethyl)phenoxy)(methoxy)phosphoryl)butanoic acid
Benzeneacetic acid, 3-[[(3-amino-3-carboxypropyl)methoxyphosphinyl]oxy]- | [Molecular Formula]
C13H18NO7P | [MDL Number]
MFCD11973895 | [MOL File]
926281-37-0.mol | [Molecular Weight]
331.26 |
| Chemical Properties | Back Directory | [Boiling point ]
557.7±50.0 °C(Predicted) | [density ]
1.403±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
<33.13mg/ml in H2O; <33.13mg/ml in DMSO | [form ]
solid | [pka]
2.18±0.10(Predicted) | [color ]
White | [Cosmetics Ingredients Functions]
ANTIOXIDANT
SKIN CONDITIONING
HUMECTANT |
| Hazard Information | Back Directory | [Uses]
Nahlsgen is a highly selective, and irreversible γ-?glutamyl transpeptidase (GGT) inhibitor with no inhibitory activity on glutamine amidotransferases. | [in vivo]
GGsTop (1 mg/kg) lowers levels of ALT, AST, γ-GT at 12, 24, and 48 h after ischemia-reperfusion in rats[3].
GGsTop also reduces 4-HNE and TNF-α production, and decreases hepatic necrosis in rats[3]. | Animal Model: | Male rats (9 week old)[3] | | Dosage: | 1 mg/kg | | Administration: | Injected into the inferior vena cava for 12, 24, 48 h | | Result: | Lowered the serum levels of ALT, AST, prevented the increase of serum γ-GT levels in IR-GGsTop group. |
| [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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