ChemicalBook--->CAS DataBase List--->928-51-8

928-51-8

928-51-8 Structure

928-51-8 Structure
IdentificationMore
[Name]

4-Chloro-1-butanol
[CAS]

928-51-8
[Synonyms]

4-CHLORO-1-BUTANOL
4-CHLOROBUTANOL
4-CHLOROBUTANOL-1
TETRAMETHYLENE CHLOROHYDRIN
1-Butanol, 4-chloro-
4-Chlorbutan-1-ol
4-Chloro-1-butane-ol
4-chloro-1-butano
4-Chloro-1-hydroxybutane
4-Chlorobutane-1-ol
4-Chlorolbutanol
4-Chloro-n-butylclcohol
Tetramethylenechlorohydrine
4-Chloro-1-butanol, Pract.
4-chlorobutan-1-ol
4-Choro-1-bytanol
4-CHLORO-1-BUTANOL, TECH., CA. 85%
4-Chloro-1-butanol, balance THF andHCl, 85%
4-CHLORO-1-BUTANOL TECH 85%
4-CHLORO-1-BUTANOL GC ABOUT 90%
[EINECS(EC#)]

213-175-5
[Molecular Formula]

C4H9ClO
[MDL Number]

MFCD00002967
[Molecular Weight]

108.57
[MOL File]

928-51-8.mol
Chemical PropertiesBack Directory
[Appearance]

CLEAR COLOURLESS LIQUID
[Boiling point ]

84-85 °C/16 mmHg (lit.)
[density ]

1.088 g/mL at 25 °C(lit.)
[refractive index ]

n20/D 1.453(lit.)
[Fp ]

97 °F
[storage temp. ]

2-8°C
[solubility ]

Soluble in methanol, chloroform, and dimethyl sufoxide.
[form ]

Liquid
[pka]

15.01±0.10(Predicted)
[color ]

Clear colorless to light yellow
[BRN ]

1731408
[InChIKey]

HXHGULXINZUGJX-UHFFFAOYSA-N
[CAS DataBase Reference]

928-51-8(CAS DataBase Reference)
[NIST Chemistry Reference]

4-Chloro-1-butanol(928-51-8)
[EPA Substance Registry System]

928-51-8(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xn,C,F
[Risk Statements ]

R10:Flammable.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R34:Causes burns.
[Safety Statements ]

S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S16:Keep away from sources of ignition-No smoking .
[RIDADR ]

UN 2920 8/PG 2
[WGK Germany ]

3
[RTECS ]

EL1325000
[Hazard Note ]

Harmful
[TSCA ]

Yes
[HazardClass ]

3.2
[PackingGroup ]

III
[HS Code ]

29055910
[Safety Profile]

Moderately toxic by ingestion. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORIDES and ALCOHOLS.
Raw materials And Preparation ProductsBack Directory
[Preparation Products]

1-(4-(Pyrrolidin-1-yl)butyl)hydrazine-->1-(4-Morpholinobutyl)hydrazine-->2-(3-CHLOROPROPYL)-1,3-DIOXOLANE-->1-Bromo-4-chlorobutane-->4-Amino-1-butanol-->4-CHLORO-BUTYRALDEHYDE-->1,3-dioxepan-2-one
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

4-Chloro-1-butanol(928-51-8).msds
Hazard InformationBack Directory
[Chemical Properties]

CLEAR COLOURLESS LIQUID
[Uses]

Tetramethylene chlorohydrin is used inorganic synthesis.
[Uses]

4-Chloro-1-butanol was employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.
[Uses]

4-Chloro-1-butanol is employed as an internal standard in the analysis of genotoxic impurities in active pharmaceutical ingredients by GC-MS technique.
[Definition]

ChEBI: A primary alcohol that is butan-1-ol substituted by a chloro group at position 4.
[General Description]

4-Chloro-1-butanol, an alkylating agent, is one of the genotoxic impurity in active pharmaceutical ingredients. Reaction of 4-chloro-1-butanol and Reichardt′s dye has been monitored spectrophotometrically for the determination of genotoxic impurities in pharmaceuticals.
[Health Hazard]

The toxicity of this compound is low. How ever, the acute toxic symptoms are those ofethylene and propylene chlorohydrins. Oralintake of this compound caused muscle con traction, gastrointestinal pain, ulceration, andliver injury in test animals.
LD50 value, oral (mice): 990 mg/kg
Tetramethylene chlorohydrin caused tumorsin lungs in test animals. Its carcinogenicity,however, is not yet fully established.
[Fire Hazard]

Flammable; flash point 36°C (97°F); vapor density 3.7 (air = 1); the vapor forms an explosive mixture with air, range is not reported. Fire-extinguishing agent: “alcohol” foam; a water spray may be used to cool fire-exposed containers and to flush any spill. It decomposes to HCl and tetrahydrofuran on heating.
[Waste Disposal]

Tetramethylene chlorohydrin is burned ina chemical incinerator equipped with anafterburner and scrubber.
Spectrum DetailBack Directory
[Spectrum Detail]

4-Chloro-1-butanol(928-51-8)MS
4-Chloro-1-butanol(928-51-8)13CNMR
4-Chloro-1-butanol(928-51-8)IR1
4-Chloro-1-butanol(928-51-8)Raman
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

4-Chloro-1-butanol, balance THF andHCl, 85%(928-51-8)
[Alfa Aesar]

4-Chloro-1-butanol, tech. 85%(928-51-8)
[Sigma Aldrich]

928-51-8(sigmaaldrich)
[TCI AMERICA]

4-Chloro-1-butanol  (contains varying amounts of Tetrahydrofuran),>85.0%(GC)(928-51-8)
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