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931399-19-8

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931399-19-8 Structure

931399-19-8 Structure
IdentificationBack Directory
[Name]

N-[[1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl]carbonyl]glycine
[CAS]

931399-19-8
[Synonyms]

GSK360A
N-[[1-(2-Cyclopropylethyl)-6-fluoro-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl]carbonyl]glycine
N-[[1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl]carbonyl]glycine
Glycine, N-[[1-(2-cyclopropylethyl)-6-fluoro-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl]carbonyl]-
[Molecular Formula]

C17H17FN2O5
[MDL Number]

MFCD27977959
[MOL File]

931399-19-8.mol
[Molecular Weight]

348.326
Chemical PropertiesBack Directory
[Melting point ]

194-198°C (dec.)
[storage temp. ]

2-8°C
[solubility ]

Acetone (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
[form ]

powder
[color ]

white to beige
[InChI]

1S/C17H17FN2O5/c18-10-3-4-12-11(7-10)15(23)14(16(24)19-8-13(21)22)17(25)20(12)6-5-9-1-2-9/h3-4,7,9,23H,1-2,5-6,8H2,(H,19,24)(H,21,22)
[InChIKey]

TYHRZQVUPPODPT-UHFFFAOYSA-N
[SMILES]

OC(C1=C(N2CCC3CC3)C=CC(F)=C1)=C(C(NCC(O)=O)=O)C2=O
Safety DataBack Directory
[WGK Germany ]

WGK 3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Chemical Properties]

Beige Solid
[Uses]

GSK360A orally active HIF-PHD inhibitor. GSK360A exerts systemic and local effects by stabilizing HIF-1α signaling and improves long-term ventricular function, remodeling, and vascularity in a model of established ventricular dysfunction. These findings suggest that GSK360A may be suitable for the treatment of post-MI remodeling and heart failure.
[in vivo]

GSK360A (30 mg/kg i.g.) improves long-term ventricular function, remodeling, and vascularity in a model of established ventricular dysfunction[1].

Animal Model:male Lewis rats with ventricular dysfunction model[1]
Dosage:30 mg/kg
Administration:oral gavage
Result:Increased circulating levels of erythropoietin and hemoglobin and hemoxygenase-1 expression in the heart and skeletal muscle of male rats.
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