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Tec-IN-21 is a Tec kinase inhibitor. Tec-IN-21 blocks unconventional secretion of fibroblast growth factor 2 (FGF2). | [Uses]
Tec-IN-1 (Compound 21) is a Tec inhibitor (IC50s of 11.7 μM). Tec-IN-1 inhibits Tec-mediated tyrosine phosphorylation of FGF2, and inhibits FGF2 secretion from cells[1]. | [References]
[1] La Venuta G, et al. Small Molecule Inhibitors Targeting Tec Kinase Block Unconventional Secretion of Fibroblast Growth Factor 2. J Biol Chem. 2016 Aug 19;291(34):17787-803. DOI:10.1074/jbc.M116.729384 |
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