| Identification | More | [Name]
4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol | [CAS]
29700-22-9 | [Synonyms]
4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol
4-[(E)-2-(3,5-Dihydroxyphenyl)ethenyl]benzene-1,3-diol | [EINECS(EC#)]
608-401-8 | [Molecular Formula]
C14H12O4 | [MDL Number]
29072990 | [Molecular Weight]
244.24 | [MOL File]
29700-22-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
201-202.5 °C | [Boiling point ]
523.8±30.0 °C(Predicted) | [density ]
1.468±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Ethyl Acetate (Slightly), Methanol | [form ]
Solid | [pka]
9.14±0.10(Predicted) | [color ]
Pale Yellow to Pale Beige | [Cosmetics Ingredients Functions]
SKIN PROTECTING
BLEACHING
SKIN CONDITIONING | [InChI]
InChI=1S/C14H12O4/c15-11-4-3-10(14(18)8-11)2-1-9-5-12(16)7-13(17)6-9/h1-8,15-18H/b2-1+ | [InChIKey]
PDHAOJSHSJQANO-OWOJBTEDSA-N | [SMILES]
C1(O)=CC=C(/C=C/C2=CC(O)=CC(O)=C2)C(O)=C1 | [CAS DataBase Reference]
29700-22-9(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Oxyresveratrol is an effective tyrosinase inhibitor, and has anti-tussive and anti-asthmatic, antioxidant, anti-inflammatory and analgesic effects. | [Chemical Properties]
White powder | [Uses]
Oxyresveratrol is a natural hydroxystilbene with similar bioactivity to resveratrol. COX-1 inhibitor like resveratrol (R150000), anti-cancer agent. | [Definition]
ChEBI: Oxyresveratrol is a stilbenoid. | [Biological Activity]
Oxyresveratrol is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. It effectively scavenges H2O2, NO (IC50 = 45.3 μM), and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 μM)
In vitro:
1)oxyresveratrol exhibited more than 50% inhibition at 100 μM on L-tyrosine oxidation by murine tyrosinase activity.
2) oxyresveratrol showed an IC50 value of 52.7 μM on the enzyme activity.
3) oxyresveratrol works through reversible inhibition of tyrosinase activity rather than suppression of the expression and synthesis of the enzyme.
In vivo:
1) Oxyresveratrol (10 or 20 mg/kg) significantly reduced the brain infarct volume by approximately 54% and 63%, respectively, when compared to vehicle-treated MCAO rats.
2) oxyresveratrol treatment diminished cytochrome c release and decreasedcaspase-3 activation in MCAO rats. | [Solubility in organics]
Oxyresveratrol is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide, which should be purged with an inert gas. The solubility of oxyresveratrol in these solvents is approximately 50 mg/ml. | [storage]
Store at -20°C |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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