| Hazard Information | Back Directory | [Description]
N 1518 has alpha, beta-adrenergic blocking, antihypertensive and vasodilating properties. | [Uses]
N-1518 is an α and β adrenergic receptor blocker that has competitive antagonism against β1 and α1 receptors, but does not show selectivity for β1 receptors, but shows about 20-fold selectivity for α1 receptors. N-1518 has vasodilatory effects and can be used in the research field of hypertension treatment[1]. | [References]
[1] T Sugai, et al. [Pharmacological properties of (+/-)-4-[2-hydroxy-3-(3-(2-methoxyphenoxy)-2-propylamino) propoxy]-1 (2H)-isoquinolinone (N-1518), a new combined alpha-and beta-adrenoceptor blocking drug]. Nihon Yakurigaku zasshi. Folia Pharmacologica Japonica 96.3 (1990): 117-127. DOI:10.1254/fpj.96.3_117 |
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