| Identification | More | [Name]
2-(1-PIPERAZINYL)PYRIMIDINE DIHYDROCHLORIDE | [CAS]
94021-22-4 | [Synonyms]
1-(2-PYRIMIDYL)PIPERAZINE DIHYDROCHLORIDE
2-(1-PIPERAZINYL)PYRIMIDINE DIHYDROCHLORIDE
2-PIPERAZINOPYRIMIDINE DIHYDROCHLORIDE
TIMTEC-BB SBB003236
2-piperazinylpyrimidine dihydrochloride
2-Piperazin-1-yl-pyrimidine Dihydrochloride
1-(2-PYRIMIDYL)PIPERAZINE DIHYDROCHLORI&
1-(2-Pyrimidyl)piperazine2HCl
2-(1-Piperazinyl)pyrimidine dihydrochloride, 98+%
2-(1-Piperazinyl)pyrimidine dihydrochloride, 2-Piperazinopyrimidine dihydrochloride
1-(2-Pyrimidinyl)piperazine dihydrochloride, 98+% | [EINECS(EC#)]
301-415-2 | [Molecular Formula]
C8H14Cl2N4 | [MDL Number]
MFCD00012779 | [Molecular Weight]
237.13 | [MOL File]
94021-22-4.mol |
| Chemical Properties | Back Directory | [Appearance]
WHITE TO VERY SLIGHTLY BEIGE POWDER | [Melting point ]
282-287 °C(lit.) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
Powder | [color ]
White to very slightly beige | [Sensitive ]
Hygroscopic | [BRN ]
151178 | [InChI]
1S/C8H12N4.2ClH/c1-2-10-8(11-3-1)12-6-4-9-5-7-12;;/h1-3,9H,4-7H2;2*1H | [InChIKey]
ZNZGJSLHXOMREP-UHFFFAOYSA-N | [SMILES]
Cl[H].Cl[H].C1CN(CCN1)c2ncccn2 | [CAS DataBase Reference]
94021-22-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
UV9702000 | [F ]
3-10 | [HS Code ]
29335990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE TO VERY SLIGHTLY BEIGE POWDER | [Uses]
1-(2-Pyrimidinyl)piperazine-d8 (2-Piperazinylpyrimidine-d8) dihydrochloride is deuterium-labeled 1-(2-Pyrimidinyl)piperazine dihydrochloride (HY-W004148)[1]. | [in vivo]
Isotopic labels can non-invasively track the distribution, transformation and clearance of compounds and their metabolites in the body through techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR), which is beneficial to the study of pharmacometabolic kinetics (ADME).
Isotope labeling can reveal specific steps in metabolic pathways. Using compounds with stable isotope labels at specific locations directly in humans or animal models can also help verify drug mechanisms and evaluate unexpected side effects, improving the accuracy and efficiency of clinical research[3]. | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Smith K A, et al. Soil and environmental analysis[M]. Marcel Dekker Incorporated, 2000.
[3] Fan T W M, et al. Stable isotope-resolved metabolomics and applications for drug development[J]. Pharmacology & therapeutics, 2012, 133(3): 366-391. DOI:10.1016/j.pharmthera.2011.12.007 |
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