| Identification | Back Directory | [Name]
BenzaMide, 3-[[4-[(5-hydroxy-2-Methylphenyl)aMino]-2-pyriMidinyl]aMino]- | [CAS]
944795-06-6 | [Synonyms]
Lck inhibitor 2
3-[[4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl]amino]-
3-[[4-(5-hydroxy-2-methylanilino)pyrimidin-2-yl]amino]benzamide
3-[[4-[(5-Hydroxy-2-methylphenyl)amino]-2-pyrimidinyl]amino]benzamide
BenzaMide, 3-[[4-[(5-hydroxy-2-Methylphenyl)aMino]-2-pyriMidinyl]aMino]- | [Molecular Formula]
C18H17N5O2 | [MDL Number]
MFCD18206813 | [MOL File]
944795-06-6.mol | [Molecular Weight]
335.36 |
| Chemical Properties | Back Directory | [Boiling point ]
615.3±65.0 °C(Predicted) | [density ]
1.389±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO : 20 mg/mL (59.64 mM; Need ultrasonic) | [form ]
Powder | [pka]
9.92±0.18(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Lck inhibitor 2 is a multi-target tyrosine kinase inhibitor with IC50s of 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively. | [References]
[1] Bamborough, et al. Assessment of Chemical Coverage of Kinome Space and Its Implications for Kinase Drug Discovery. Journal of Medicinal Chemistry (2008), 51(24), 7898-7914. DOI:10.1021/jm8011036
[2] Bamborough, Paul, et al. N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: Indazoles as phenol isosteres with improved pharmacokinetics. Bioorganic & Medicinal Chemistry Letters (2007), 17(15), 4363-4368. DOI:10.1016/j.bmcl.2007.04.029
[3] Awale, Mahendra, et al. Molecular docking guided 3D-QSAR CoMFA analysis of N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of leukocyte-specific protein tyrosine kinase. Journal of Molecular Modeling (2008), 14(10), 937-947. DOI:10.1007/s00894-008-0334-8 |
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| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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