| Identification | More | [Name]
3-Mercapto-1,2-propanediol | [CAS]
96-27-5 | [Synonyms]
1-THIOGLYCEROL
3-MERCAPTO-1,2-PROPANDIOL
3-MERCAPTO-1,2-PROPANEDIOL
ALPHA-MONOTHIOGLYCEROL
ALPHA-THIOGLYCEROL
A-MONOTHIOGLYCEROL
MERCAPTOGLYCEROL
MONOTHIOGLYCEROL
THIOGLYCERIN
THIOGLYCEROL
1,2-Propanediol, 3-mercapto-
1-Mercapto-2,3-propanediol
1-Mercaptoglycerol
1-Monothioglycerol
1-Thio-2,3-propanediol
1-Thiogylcerol
2,3-Dihydroxypropanethiol
3-mercapto-propane-1,2-diol
3-Mercaptopropane-1,2-diol
3-Sulfanyl-1,2-propanediol | [EINECS(EC#)]
202-495-0 | [Molecular Formula]
C3H8O2S | [MDL Number]
MFCD00004879 | [Molecular Weight]
108.16 | [MOL File]
96-27-5.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to yellowish viscous solution | [Melting point ]
<25 °C | [Boiling point ]
118 °C5 mm Hg(lit.)
| [density ]
1.25 g/mL at 25 °C(lit.)
| [vapor pressure ]
<1 hPa (20 °C) | [refractive index ]
n20/D 1.527(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
absolute ethanol: 1 mL/mL
| [form ]
liquid
| [pka]
pK1:9.43 (25°C,μ=0.5) | [color ]
Clear colorless to yellow | [Odor]
Stench odour | [PH]
3.5-7.0 | [biological source]
synthetic (organic) | [Water Solubility ]
slightly soluble | [Sensitive ]
Air Sensitive & Hygroscopic | [Merck ]
14,9335 | [BRN ]
1732046 | [Stability:]
Air Sensitive, Hygroscopic | [Cosmetics Ingredients Functions]
DEPILATORY
KERATOLYTIC
HAIR WAVING OR STRAIGHTENING
REDUCING | [InChI]
1S/C3H8O2S/c4-1-3(5)2-6/h3-6H,1-2H2 | [InChIKey]
PJUIMOJAAPLTRJ-UHFFFAOYSA-N | [SMILES]
OCC(O)CS | [LogP]
-0.84 at 20℃ | [CAS DataBase Reference]
96-27-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Monothioglycerol(96-27-5) | [EPA Substance Registry System]
96-27-5(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H302-H311-H315-H317 | [Precautionary statements ]
P280-P301+P312+P330-P302+P352+P312 | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R21/22:Harmful in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) . | [RIDADR ]
UN 2810 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
TY8140000
| [F ]
3-9-10-13-23 | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29309070 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 4 Oral
Skin Irrit. 2
Skin Sens. 1B | [Safety Profile]
Poison by
intraperitoneal and intravenous routes.
Experimental reproductive effects. Mutation
data reported. Flammable when exposed to
heat or flame; can react with oxidizing
materials. When heated to decomposition it
emits hghly toxic fumes of SOx. | [Hazardous Substances Data]
96-27-5(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Description]
1-Thioglycerol is a reagent used in fluorescence, spectroscopy, and microbiology techniques. Varying the concentration of 1-thioglycerol in the preparation of CdSe/CdS core-shell ultrasmall quantum dots (CS-USQDs) allows a precise way to control the size of the shell, with shell size increasing with increased concentration.1 It is used as a capping agent in the synthesis of nanocrystals analyzed via Raman and UV/Vis spectroscopy.2,3 Biologically, 1-thioglycerol stimulates porphyrin synthesis and increases glutamyl-tRNA reductase activity in E. coli grown in an aerobic environment.4 It was previously a component in hair permanents used to produce waves or curls.5 | [Chemical Properties]
clear colorless to yellowish viscous solution | [Chemical Properties]
Monothioglycerol occurs as a colorless or pale-yellow colored,
viscous, hygroscopic liquid with a slight odor of sulfide. | [Uses]
3-Mercapto-1,2-propanediol can be used as antioxidant preservative; reagent in analytical chemistry, cell culture research. Matrix substrate in fast atom bombardment mass spectrometry.
| [Uses]
3-Mercapto-1,2-propanediol has been used in a study to assess the manipulation of aqueous growth of CdTe nanocrystals. It has also been used in a study that investigated the effect of surface attachment on ligand binding
| [Definition]
ChEBI: A thiol that is glycerol in which one of the primary hydroxy groups is replaced by a thiol group. | [Production Methods]
Monothioglycerol is prepared by heating an ethanolic solution of 3-
chloro-1,2-propanediol with potassium bisulfide. | [General Description]
1-Thioglycerol stimulates the synthesis of porphyrin in aerobically growing Escherichia coli. It is an inhibitor of glycerol kinase activity in vitro and in situ. | [Pharmaceutical Applications]
Monothioglycerol is used as an antioxidant in pharmaceutical
formulations, mainly in parenteral preparations.Monothioglycerol
is reported to have some antimicrobial activity.It is also
widely used in cosmetic formulations such as depilating agents.
Therapeutically, monothioglycerol has been used in a 0.02%
w/w aqueous solution to stimulate wound healing, and as a 0.1%
w/w jelly in atrophic rhinitis. | [Safety]
Monothioglycerol is generally regarded as a relatively nontoxic and
nonirritant material at the concentrations used as a pharmaceutical
excipient. It is used in topical and injectable preparations.
Undiluted monothioglycerol is considered a poison by the IP and
IV routes; it has also been reported to be mutagenic.
LD50 (cat, IV): 0.22 g/kg
LD50 (mouse, IP): 0.34 g/kg
LD50 (rabbit, IV): 0.25 g/kg
LD50 (rat, IP): 0.39 g/kg | [storage]
Monothioglycerol is unstable in alkaline solutions. Monothioglycerol
should be stored in a well-closed container in a cool, dry place. | [Incompatibilities]
Monothioglycerol can react with oxidizing materials. | [Regulatory Status]
Included in the FDA Inactive Ingredients Database (IM, IV and
other injections). Included in the Canadian List of Acceptable Nonmedicinal
Ingredients. | [References]
[1] ANIELLE CHRISTINE A. SILVA. Shell Thickness Modulation in Ultrasmall CdSe/CdSxSe1–x/CdS Core/Shell Quantum Dots via 1-Thioglycerol[J]. ACS Nano, 2014, 8 2: 1913-1922. DOI: 10.1021/nn406478f
[2] YANFEI WANG. Raman scattering study of molecules adsorbed on ZnS nanocrystals[J]. Journal of Raman Spectroscopy, 2006, 38 1: 34-38. DOI: 10.1002/jrs.1570
[3] M. T. HARRISON. Wet Chemical Synthesis of Highly Luminescent HgTe/CdS Core/Shell Nanocrystals[J]. Advanced Materials, 1999, 12 2: 123-125. DOI: 10.1002/(sici)1521-4095(200001)12:2<123::aid-adma123>3.0.co;2-h
[4] G T JAVOR E F F. Enzymatic basis of thiol-stimulated secretion of porphyrins by Escherichia coli.[J]. Journal of Bacteriology, 1992, 174 3: 1072-1075. DOI: 10.1128/jb.174.3.1072-1075.1992
[5] LEHMAN A J. HEALTH ASPECTS OF COMMON CHEMICALS USED IN HAIR-WAVING PREPARATIONS[J]. JAMA neurology, 1949, 27 7 1: 842-845. DOI: 10.1001/jama.1949.62910120002010 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|