| Identification | Back Directory | [Name]
MPEP | [CAS]
96206-92-7 | [Synonyms]
MPEP
CS-715
MPEP,HCl
MPEP 100MG
MPEP USP/EP/BP
MPEP HYDROCHLORIDE
2-methyl-6-(2-phenylethynyl)pyridine
Pyridine, 2-methyl-6-(2-phenylethynyl)-
6-METHYL-2-(PHENYLETHYNYL)-PYRIDINE HCL
2-METHYL-6-(PHENYLETHYNYL)PYRIDINE HYDROCHLORIDE | [Molecular Formula]
C14H12ClN | [MDL Number]
MFCD02262119 | [MOL File]
96206-92-7.mol | [Molecular Weight]
229.7 |
| Chemical Properties | Back Directory | [Melting point ]
45-45.5 °C | [Boiling point ]
124.5-126.5 °C(Press: 0.5 Torr) | [density ]
1.10±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at +4°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Off-white powder. | [pka]
2.97±0.12(Predicted) | [color ]
White to Off-White | [Stability:]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
A potent, subtype selective mGluR5 antagonist | [Definition]
ChEBI: 2-methyl-6-(phenylethynyl)pyridine is a methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. It has a role as a metabotropic glutamate receptor antagonist and an anxiolytic drug. It is a member of methylpyridines and an acetylenic compound. It is a conjugate base of a 2-methyl-6-(phenylethynyl)pyridinium(1+). It derives from a hydride of an acetylene. | [Biological Activity]
Potent and highly selective non-competitive antagonist at the mGlu 5 receptor subtype (IC 50 = 36 nM) and a positive allosteric modulator at mGlu 4 receptors. Centrally active following systemic administration in vivo . Reverses mechanical hyperalgesia in the inflamed rat hind paw. Also available as part of the Group I mGlu Receptor Tocriset™ . | [References]
[1] gasparini f, lingenh?hl k, stoehr n, et al. 2-methyl-6-(phenylethynyl)-pyridine (mpep), a potent, selective and systemically active mglu5 receptor antagonist. neuropharmacology, 1999, 38(10): 1493-1503.
[2] tatarczyńska e, k?odzińska a, chojnacka-wójcik e, et al. potential anxiolytic-and antidepressant-like effects of mpep, a potent, selective and systemically active mglu5 receptor antagonist. british journal of pharmacology, 2001, 132(7): 1423-1430. |
|
|