| Identification | More | [Name]
4-Chloro-3-nitrobenzenesulfonyl chloride | [CAS]
97-08-5 | [Synonyms]
2-CHLORO-1-NITROBENZENE-5-SULFONYL CHLORIDE
3-NITRO-4-CHLOROBENZENESULFONYL CHLORIDE
3-NITRO-4-CHLOROBENZENSULFONYL CHLORIDE
4-CHLORO-3-NITROBENZENE-1-SULFONYL CHLORIDE
4-CHLORO-3-NITROBENZENESULFONYL CHLORIDE
4-CHLORO-3-NITROBENZENESULPHONYL CHLORIDE
YELLOW SULFON CHLORIDE
4-chloro-3-nitro-benzenesulfonylchlorid
3-Nitro-4-chlorobenzensulfonyl
4-Chloro-3-nitrobenzenesulphonyl chloride 98%
3-NITRO-4-CHLOROBENZENESULFONYL CHLORIDE,98%+
3-Nitro-4-chlorobenzenesulfonic acid chloride | [EINECS(EC#)]
202-558-2 | [Molecular Formula]
C6H3Cl2NO4S | [MDL Number]
MFCD00007440 | [Molecular Weight]
256.06 | [MOL File]
97-08-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns.
R29:Contact with water liberates toxic gas.
R14:Reacts violently with water. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S8:Keep container dry .
S30:Never add water to this product .
S22:Do not breathe dust . | [RIDADR ]
UN 3261 8/PG 2
| [WGK Germany ]
3
| [Hazard Note ]
Corrosive | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29049090 |
| Hazard Information | Back Directory | [Chemical Properties]
LIGHT BROWN CRYSTALLINE POWDER | [Uses]
4-Chloro-3-nitrobenzenesulfonyl chloride can be used:
- In the preparation of functionalized 1H-indenes via copper-catalyzed arylative cyclization.
- As a precursor in the synthesis of N-arylsulfonyl-3-acylindole arylcarbonyl hydrazone derivatives that show potential nematicidal activity.
- As a key starting material in the synthesis of sulfonamide analogs of ferrostatin-1 (fer-1), which possess good ferroptosis inhibition property.
- In the synthesis of 4-chloro-3-nitrobenzene thiol.
| [Uses]
4-Chloro-3-nitrobenzenesulfonyl Chloride is used in the synthesis of novel sulfonamide derivatives of tricyclic thieno[2,3-d]pyrimidin-4(3H)-ones which increases melanin synthesis in murine B16 cells. | [Synthesis]
Synthesis Example 2-2 Synthesis of 4-chloro-3-nitrobenzenesulfonyl chloride: to a reaction vial containing a mixture of 1280 g of potassium 4-chloro-3-nitrobenzenesulfonate, 1150 mL of acetonitrile, 250 mL of sulfoxide, and 30 mL of dimethylacetamide, 1240 mL of phosphinic acid chloride was added dropwise at a slow rate, while controlling the temperature within the reaction system to maintain a temperature of 60°C to 70°C. After the dropwise addition was completed, the reaction mixture was stirred at 73°C for 3 hours. Upon completion of the reaction, the reaction mixture was cooled with water, followed by the slow addition of 400 mL of water. The reaction mixture was poured into 5 L of ice water and the precipitated crystals were separated by filtration, washed with water and dried to give 1060 g of the target product 4-chloro-3-nitrobenzenesulfonyl chloride in 84% yield. The melting point of the product was 55 °C to 56 °C. | [References]
[1] Patent: US5221750, 1993, A
[2] Patent: US5071994, 1991, A |
|
|