| Identification | More | [Name]
Drotaverine hydrochloride | [CAS]
985-12-6 | [Synonyms]
DROTAVERINE HCL
DROTAVERINE HYDROCHLORIDE
1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydro-isoquinolin
drotaveriniumchloride
isoquinoline,1,2,3,4-tetrahydro-6,7-diethoxy-1-((3,4-diethoxyphenyl)methylene)
no-spa
no-spahydrochloride
tetraspasmin-lefa
DROTAVERINE HCL ,1-[(3,4-DIETHOXYPHENYL)METHYLENE]-6,7-DIETHOXY 1,2,3,4-TETRAHYDROISOQUINOLINE HCL
Drotaverinehydrochlorid
1-(3,4-Diethoxybenzylidine)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
1-[(3,4-Diethoxyphenyl)methylene]-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride
NOSH-BRA
Tetraspasmin-Lef
1,2,3,4-Tetrahydro-6,7-diethoxy-1-((3,4-diethoxyphenyl) methylene)-isoquinoline hydrochloride | [EINECS(EC#)]
619-357-4 | [Molecular Formula]
C24H32ClNO4 | [MDL Number]
MFCD01754602 | [Molecular Weight]
433.97 | [MOL File]
985-12-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Pale-Yellow Crystalline Solid | [Melting point ]
208-212°C | [storage temp. ]
-20°C Freezer | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
Yellow | [Usage]
Analogue of Papaverine. Antispasmodic | [InChI]
InChI=1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H/b20-13+; | [InChIKey]
JBFLYOLJRKJYNV-UNUAAEKOSA-N | [SMILES]
C1(=C/C2=CC=C(OCC)C(OCC)=C2)/C2=C(C=C(OCC)C(OCC)=C2)CCN/1.[H]Cl | [CAS DataBase Reference]
985-12-6(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Pale-Yellow Crystalline Solid | [Uses]
A papaverine analog | [Uses]
Analogue of Papaverine. Antispasmodic | [Biological Activity]
Drotaverine (Drotaverin) is an isoquinoline-based PDE4-selective phosphodiesterase (PDE) inhibitor and an L-type voltage-dependent (voltage-operated) calcium channel (L-VDCC or L-VOCC) blocker th at exhibits in vivo antispasmodic efficacy without anticholinergic effects.''It is a benzylisoquinoline derivative. Drotaverine acts as a smooth muscle relaxant. | [in vivo]
Drotaverine (10-80 mg/kg, i.p., single dose) hydrochloride improves cognitive impairment and shows the ability to regulate levels of neurotransmitters in the brain[3]. | Animal Model: | STZ-induced AD white mice [3] | | Dosage: | 10, 20, 40, 80 mg/kg; single dose | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Increased physical activity in a dose-dependent manner, with more time spent in the open arms, increased in the number of crossings and time spent in the north quadrant.
Increased in brain antioxidant levels (SOD, CAT, GSH), a reduction in nitrite levels, and significant increased in serotonin, dopamine, and norepinephrine levels. |
| [IC 50]
L-type calcium channel; PDE4 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Aemon Chemical
|
| Telephone: |
0086-755-86198205 |
| Website: |
www.aemonchem.com |
|