| Identification | Back Directory | [Name]
ethaverine hydrochloride | [CAS]
985-13-7 | [Synonyms]
Cebral
Isovex
Consenil
Ethaquin
Balborin
Barbonin hydrochloride
ethaverine hydrochloride
Ethylpapaverin hydrochloride
6,7-Diethoxy-1-(3,4-diethoxybenzyl)isoquinoline hydrochloride
Isoquinoline, 1-(3,4-diethoxybenzyl)-6,7-diethoxy-, hydrochloride
Isoquinoline, 1-[(3,4-diethoxyphenyl)methyl]-6,7-diethoxy-, hydrochloride | [EINECS(EC#)]
213-573-9 | [Molecular Formula]
C24H29NO4.ClH | [MOL File]
985-13-7.mol | [Molecular Weight]
431.957 |
| Hazard Information | Back Directory | [Uses]
Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease[1][2][3]. | [Safety Profile]
Poison by intravenous route. Moderately toxic by subcutaneous route. When heated to decomposition it emits toxic vapors of NOx, HCl, and Clí | [in vivo]
Ethaverine hydrochloride (2-10 mg/kg, intravenous infusion, i.v.) causes significant elevation of endocochlear potential in guinea pigs[4].
Ethaverine (1-10 mg/kg, i.v.) inhibits atrioventricular conduction and heart rate in the anaesthetized dog[5].
| Animal Model: | Dog[5] | | Dosage: | 1 and 10 mg/kg | | Administration: | i.v. | | Result: | Inhibited atrioventricular conduction and heart rate. |
| [References]
[1] Wang Y, et al. Ethaverine, a derivative of papaverine, inhibits cardiac L-type calcium channels. Mol Pharmacol. 1991 Nov;40(5):750-5. PMID:1658607
[2] Suh BC, et al. Inhibition by ethaverine of catecholamine secretion through blocking L-type Ca2+ channels in PC12 cells. Biochem Pharmacol. 1994 Mar 29;47(7):1262-6. DOI:10.1016/0006-2952(94)90399-9
[3] Shin JS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells. Biol Pharm Bull. 2001 Jan;24(1):103-5. DOI:10.1248/bpb.24.103
[4] Prazma J, et al. Effect of ethaverine hydrochloride on cochlear microcirculation. Arch Otolaryngol. 1981 Apr;107(4):227-9. DOI:10.1001/archotol.1981.00790400029006
[5] Lacroix P, et al. [Comparative activity of ethaverine and papaverine on chronotropic and dromotropic cardiac functions in the anesthetized dog]. Arch Int Pharmacodyn Ther. 1976 May;221(1):163-76. French. PMID:962426
[6] Lee SS, et al. Inhibitory effects of ethaverine, a homologue of papaverine, on monoamine oxidase activity in mouse brain. Biol Pharm Bull. 2001 Jul;24(7):838-40. DOI:10.1248/bpb.24.838 |
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