| Identification | Back Directory | [Name]
Bis-(Aminoxy)-PEG3 | [CAS]
98627-70-4 | [Synonyms]
Bis-(Aminoxy)-PEG3
Bis-(Aminooxy)-PEG3
Aminoxy-PEG3-Aminoxy
Aminooxy-PEG3-Aminooxy
α,ω-Diaminoxy poly(ethylene glycol)
Hydroxylamine, O,O'-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl)]bis-
O,O'-(((oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(hydroxylamine) | [Molecular Formula]
C8H20N2O5 | [MDL Number]
MFCD00519243 | [MOL File]
98627-70-4.mol | [Molecular Weight]
224.25 |
| Chemical Properties | Back Directory | [solubility ]
Soluble in DCM,H2O, DMF, DMSO | [form ]
Liquid | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C8H20N2O5/c9-14-7-5-12-3-1-11-2-4-13-6-8-15-10/h1-10H2 | [InChIKey]
DZEJMPNILLCRBD-UHFFFAOYSA-N | [SMILES]
O(CCOCCON)CCOCCON |
| Hazard Information | Back Directory | [Description]
Bis-aminooxy-PEG3 is an water soluble crosslinker containing two aminooxy groups. Aminooxy (ONH2) group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond or a hydroxylamine linkage under reduction condition Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
Bis-aminooxy-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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