| Identification | Back Directory | [Name]
Bis-aminooxy-PEG1 | [CAS]
93460-33-4 | [Synonyms]
Bis-aminooxy-PEG1
O-(2-[2-(Aminooxy)ethoxy]ethyl)hydroxylamine
Hydroxylamine, O,O'-(oxydi-2,1-ethanediyl)bis-
O,O'-(oxybis(ethane-2,1-diyl))bis(hydroxylamine) | [Molecular Formula]
C4H12N2O3 | [MDL Number]
MFCD27933532 | [MOL File]
93460-33-4.mol | [Molecular Weight]
136.15 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C, protect from light | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Bis-aminooxy-PEG1 is a PEG linker containing two aminooxy groups. The hydrophilic PEG spacer increases solubility in aqueous media. The aminooxy groups can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
Bis-aminooxy-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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