| Identification | Back Directory | [Name]
Bis-aminooxy-PEG4 | [CAS]
98627-72-6 | [Synonyms]
Bis-aminooxy-PEG4
Aminooxy-PEG4-Aminooxy
Hydroxylamine, O,O'-(3,6,9,12-tetraoxatetradecane-1,14-diyl)bis-
~{O}-[2-[2-[2-[2-(2-aminooxyethoxy)ethoxy]ethoxy]ethoxy]ethyl]hydroxylamine | [Molecular Formula]
C10H24N2O6 | [MDL Number]
MFCD30730367 | [MOL File]
98627-72-6.mol | [Molecular Weight]
268.31 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C, sealed storage, away from moisture and light | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
Bis-aminooxy-PEG4 is a homobifunctional crosslinking reagent with great water soolubility. Aminooxy (ONH2) group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond or a hydroxylamine linkage under reduction condition Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
Bis-aminooxy-PEG4 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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