| Identification | More | [Name]
Acetylleucine | [CAS]
99-15-0 | [Synonyms]
2-(ACETYLAMINO)-4-METHYLPENTANOIC ACID
AC-DL-LEU-OH
ACETYL-DL-LEUCINE
ACETYL-DL-LEUCINE, N-
acetylleucine
AKOS BBS-00004735
IFLAB-BB F0777-0821
N-ACETYL-DL-LEU
N-ACETYL-DL-LEUCINE
N-ACETYL LEUCINE
N-ALPHA-ACETYL-DL-LEUCINE
rac-(2R*)-2-(Acetylamino)-4-methylvaleric acid
rac-(R*)-2-(Acetylamino)-4-methylvaleric acid | [EINECS(EC#)]
202-734-9 | [Molecular Formula]
C8H15NO3 | [MDL Number]
MFCD00026498 | [Molecular Weight]
173.21 | [MOL File]
99-15-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
160°C | [Boiling point ]
369.7±25.0 °C(Predicted) | [density ]
1.069±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
almost transparency in EtOH | [form ]
powder to crystal | [pka]
3.67±0.10(Predicted) | [color ]
White to Almost white | [CAS DataBase Reference]
99-15-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless solid | [Uses]
antivertigo | [Definition]
ChEBI: N-acetyl-leucine is a leucine derivative and a N-acetyl-amino acid. | [World Health Organization (WHO)]
The products were indicated for the treatment of vertigo and had
been authorized for marketing under the "grandfather" clause, which waives full
registration requirements for products marketed before 1963. | [Synthesis]
Acetylleucine is synthesized from L-leucine via N-acylation with acetic anhydride in aqueous sodium hydroxide, followed by catalytic thermal racemization and purification through alkaline redissolution and acidification[1]. | [in vivo]
Acetylleucine (60 mg/kg, i.v., on days 1, 2 and 3 after unilateral labyrinthectomy (UL)) accelerates compensation of postural symptoms but not of nystagmus or head roll tilt after UL in rats[3].
| [References]
[1] Mai Van Phong, Pham Nguyen Vu, Vu Duc Thanh. Optimization and Process Scale-up for the Synthesis of Pharmaceutical-Grade N-Acetyl-DL-Leucine from L-Leucine. |
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