105627-79-0

基本信息
高哌嗪5-异喹啉磺酰胺
5-异喹啉磺酰氯,盐酸盐
异喹啉-5-磺酰氯盐酸盐
异喹啉-5-磺酰氯盐酸盐(法舒地尔中间体)
异喹啉-5-磺酰氯盐酸盐(法舒地尔中间体) 100KG
5-异喹啉磺酰氯/异喹啉-5-硫酰氯盐酸盐/法舒地尔中间体
isoquinolin-5-sulfonyl chloride HCl
Isoquinolin-5-sulphonyl chloride HCl
Isoquinoline-5-sulphonyl chloride, HCl
5-(Chlorosulphonyl)isoquinoline hydrochloride
5-Isoquinolinesulfonyl chloride, hydrochloride
ISOQUINOLINE-5-SULPHONYL CHLORIDE HYDROCHLORIDE
isoquinolin-5-ylsulphonyl chloride hydrochloride
Isoquinoline-5-sulfonyl chloride hydrochloride salt
5-Isoquinolinesulfonylchloride, hydrochloride (1:1)
制备方法

27655-40-9

105627-79-0
在室温及氮气保护下,向搅拌中的5-异喹啉磺酸(28.3 g,135 mmol)与亚硫酰氯(150 mL,2.06 mol)形成的悬浮液中缓慢滴加无水DMF(1.5 mL)。将反应混合物加热至回流状态,维持2.5小时。反应完成后,冷却至室温,随后在减压条件下浓缩,得到淡黄色粉末。将该粉末悬浮于无水二氯甲烷(200 mL)中,进行超声处理,过滤后,于40℃下减压干燥,最终获得异喹啉-5-磺酰氯盐酸盐29.2 g(111 mmol,收率82%)。产物结构经1H NMR(TFA-d)确认:δ 8.48(t,J = 7.9 Hz,1H),9.13-9.14(m,2H),9.29(d,J = 7.9 Hz,1H),9.57(d,J = 7.0 Hz,1H),10.26(s,1H)。
参考文献:
[1] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 9, p. 2317 - 2333
[2] Journal of Medicinal Chemistry, 1989, vol. 32, # 1, p. 42 - 46
[3] Journal of Medicinal Chemistry, 1989, vol. 32, # 1, p. 46 - 50
[4] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 9, p. 5277 - 5284
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 14, p. 5922 - 5933