10563-70-9
中文名称
盐酸美利曲辛
英文名称
Melitracen hydrochloride
CAS
10563-70-9
EINECS 编号
234-150-5
分子式
C21H26ClN
分子量
327.891
MOL 文件
10563-70-9.mol
更新日期
2024/04/26 08:30:25
10563-70-9 结构式
基本信息
中文别名
盐酸美利蒽盐酸美利曲辛
3-[10,10-二甲基-9(10H)-蒽亚基]-N,N-二甲基丙胺盐酸盐
英文别名
3-[10,10-dimethyl-9(10H)-anthrylidene]-N,N-dimethylpropylamine hydrochlorideMELITRACEN HYDROCHLORLD
1-Propanamine, 3-(10,10-dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-, hydrochloride
MELITRACEN HYDROCHLORID
Melitracen hydrochloride
3-(10,10-Dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl-1-propanamine Hydrochloride
9-(3-Dimethylaminopropylidene)-10,10-dimethyl-9,10-dihydroanthracene Hydrochloride
Adaptol
Melixeran
Thymeol
Trausabun
U-24973A
3-(10,10-Dimethyl-d6)-9(10H)-anthracenylidene)-N,N-dimethyl-1-propanamine Hydrochloride
9-(3-Dimethylaminopropylidene)-10,10-(dimethyl-d6)-9,10-dihydroanthracene Hydrochloride
Adaptol-d6
Melitracen-d6 Hydrochloride
Melitracene-d6
Melixeran-d6
Thymeol-d6
Trausabun-d6
所属类别
原料药：抗抑郁、躁狂药
常见问题列表
生物活性
Melitracen hydrochloride (Thymeol)是一种潜在的dopamine D1/2 receptor拮抗剂，具有抗抑郁作用。靶点
5-HT receptor
体内研究
Single oral administration of either Imipramine or Melitracen produces a marked and long lasting mydriasis in mice. The mydriatic effect of Melitracen is more marked and longer lasting. Melitracen is more effective with respect to behavioral excitement. Single oral administration of Melitracen produces lowering of the catechol amine levels in the brain stem, the cerebral cortex, the spleen, and the adrenals.
No significant changes in catecholamine levels of the brain stem, the cerebral cortex, and the spleen were observed in rats receiving daily doses of Melitracen for 13 and 15 weeks. The adrenalin level in the adrenals, however, is slightly decreased.