105956-97-6
105956-97-6 结构式
基本信息
克林沙星
1-环丙基-6-氟-7-(3-氨基吡咯烷-1- 基)-8-氯-1,4-二氢-4-氧-喹啉-3-羧酸
CLINAFLOXACIN
7-(3-Amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-8-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
3-Quinolinecarboxylic acid, 7-(3-amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-
6-Fluoro-8-chloro-1-cyclopropyl-7-(3-aminopyrrolidin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
7-(3-Aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CI-960
PD-127391
物理化学性质
常见问题列表
| Target | Value |
| Topoisomerase IV | |
| DNA gyrase |
Clinafloxacin是一个喹诺酮羧酸类的广谱抗生素，目前用于严重感染的静脉注射和口服治疗。 Clinafloxacin是一个新型的氟喹诺酮。在体外具有抗革兰氏阳性，革兰氏阴性，和厌氧病原体的广谱活性。Clinafloxacin对肺炎链球菌7785 (MIC，0.125 微克/毫升)具有较高活性，并且非gyrA 或parC喹诺酮耐药突变单独对该活性具有更好的作用。与ofloxacin，levofloxacin，sparfloxacin，grepafloxacin，以及trovafloxacin相比，Clinafloxacin被认为是最有效的抗S. pneumoniae氟喹诺酮，目前被认为是一个抗肺炎链球菌药。
Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model. With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis.