121062-08-6
121062-08-6 结构式
基本信息
美那诺坦II
美拉诺坦 II
[ACETYL-NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MSH (4-10) AMIDE
(ACETYL-NLE4,ASP5,D-PHE7,LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE ACETATE SALT
AC-[NLE4, ASP5, D-PHE7, LYS10]-ALPHA-MSH (4-10)-NH2
(AC-NLE4, ASP5, DPHE7, LYS10)-CYCLO-ALPHA-MSH (4-10) AMIDE
AC-NLE4-C[ASP5, D-PHE7, LYS10]ALPHA-MSH (4-10)-NH2
AC-NLE-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2
AC-NLE-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2, ASP5-LYS10, CYCLIC LACTAM
AC-NLE-C[+ASP-HIS-DPHE-ARG-TRP-LYS]-NH2
AC-NLE-CYCLO(-ASP-HIS-D-PHE-ARG-TRP-LYS-NH2) ACETATE SALT
AC-NLE-CYCLO(-BETA-ASP-HIS-D-PHE-ARG-TRP-EPSILON-LYS-NH2)
AC-NLE-CYCLO[(BETA-D)-HFRW-(EPSILON-K)]-NH2
MELANOTAN II
MTII
[N-ACETYL-NLE4,ASP5,D-PHE7,LYS10]-ALPHA-MSH (4-10) AMIDE ASP5-LYS10, CYCLIC LACTAM
Ac-[Nle4Asp5D-Phe7Lys10]α-MSH-(4-10)-NH2
Melanotan Ц
Melanotan 2
MalanotanIi
Mt-Ii(Melanotan)
物理化学性质
常见问题列表
美拉诺坦 II 是一种实验室制造的化学物质，与人体内的激素相似。美拉诺坦 II 已被证明对人类具有黑色素生成（鞣制）和壮阳作用。
Melanotan (MT)-II is a potent non-selective melanocortin receptor agonist with high affinity for MC1, MC3, MC4, and MC5 receptor subtypes which are involved in the regulation of a number of physiological systems such as the pigmentary system, energy homoeostasis, sexual functioning, the immune system, inflammation, and the cardiovascular system.
Melanotan (MT)-II exerts a dose-dependent inducer activity on erection by eliciting erectile events and shortening latency of the first erectile event to occur. Erectile responses elicited by cavernous nerve stimulation are increased after i.v. melanotan (MT)-II (1 mg/kg), thereby exerting facilitator effect on erection. Melanotan (MT)-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Melanotan (MT)-II significantly enhances the recovery of sensory function following a crush lesion of the sciatic nerve in the rat at a dose of 20 μg/kg per 48 h, s.c., but not at a dose of 2 or 50 μg/kg. Melanotan (MT)-II is a potent initiator of penile erection in men with erectile dysfunction. Melanotan (MT)-II reduces food intake and body weight and invokes thermogenic responses in a mouse model.