133-67-5
中文名称
三氯噻嗪
英文名称
Trichlormethiazide
CAS
133-67-5
EINECS 编号
205-118-8
分子式
C8H8Cl3N3O4S2
MDL 编号
MFCD00057315
分子量
380.66
MOL 文件
133-67-5.mol
更新日期
2026/01/13 09:56:29
133-67-5 结构式
基本信息
中文别名
三氯噻嗪 英文别名
6-CHLORO-3-DICHLOROMETHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDETRICHLORMETHIAZIDE
TRICHLOROMETHIAZIDE
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(dichloromethyl)-3,4-dihydr
3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
3-dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1
3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
3-dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-d
3-dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio
3-dichloromethylhydrochlorothiazide
6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonam
6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamid
6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-thiadiazine-7-sulfonamide1,1-dioxide
6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide
6-chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1
6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
6-chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio
Achletin
Anistadin
所属类别
原料药：利尿药物理化学性质
熔点248-250℃
沸点631.3±65.0 °C(Predicted)
密度1.748
折射率1.6000 (estimate)
储存条件Keep in dark place,Inert atmosphere,Room temperature
溶解度可溶于DMSO（少许）、甲醇（少许）
酸度系数(pKa)pKa 6.9(acetone/H2O) (Uncertain)
形态固体
颜色白色至灰白色
Merck9624
主要应用pharmaceutical (small molecule)
InChI1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)
InChIKeyLMJSLTNSBFUCMU-UHFFFAOYSA-N
SMILESNS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl
EPA化学物质信息Trichlormethiazide (133-67-5)
安全数据
知名试剂公司产品信息
Sigma Aldrich
133-67-5(sigmaaldrich)TCI Shanghai
三氯噻嗪Trichloromethiazide,>99.0%(T)(133-67-5)
三氯噻嗪价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/12/22 | HY-B0235 | 三氯噻嗪 Trichlormethiazide | 133-67-5 | 500mg | 400元 |
| 2025/12/22 | HY-B0235 | 三氯噻嗪 Trichlormethiazide | 133-67-5 | 10mM * 1mLin DMSO | 500元 |
| 2025/12/22 | HY-B0235 | 三氯噻嗪 Trichlormethiazide | 133-67-5 | 1g | 500元 |
常见问题列表
生物活性
Trichlormethiazide 是一种利尿剂，具有与Hydrochlorothiazide相似的特性。体内研究
Trichlormethiazide (10 mg/kg, i.v.; daily; for 5 days) significantly reduces mean arterial pressure (MAP) within 24 h in high salt intake (HS) rats receiving angiotensin II, but does not affect MAP in any other group.
| Animal Model: | Male Sprague-Dawley rats (350-450 g) |
| Dosage: | 10 mg/kg |
| Administration: | Intravenous injection, daily, for 15 days |
| Result: | Produced a significant fall in MAP in rats on combined angiotensin II and high salt intake. |