| Identification | More | [Name]
TRICHLORMETHIAZIDE | [CAS]
133-67-5 | [Synonyms]
6-CHLORO-3-DICHLOROMETHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE
TRICHLORMETHIAZIDE
TRICHLOROMETHIAZIDE
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide
2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(dichloromethyl)-3,4-dihydr
3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
3-dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1
3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
3-dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-d
3-dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio
3-dichloromethylhydrochlorothiazide
6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonam
6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamid
6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-thiadiazine-7-sulfonamide1,1-dioxide
6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide
6-chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1
6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
6-chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio
Achletin
Anistadin | [EINECS(EC#)]
205-118-8 | [Molecular Formula]
C8H8Cl3N3O4S2 | [MDL Number]
MFCD00057315 | [Molecular Weight]
380.66 | [MOL File]
133-67-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
248-250℃ | [Boiling point ]
631.3±65.0 °C(Predicted) | [density ]
1.748 | [refractive index ]
1.6000 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
pKa 6.9(acetone/H2O) (Uncertain) | [color ]
White to Off-White | [Merck ]
9624 | [Major Application]
pharmaceutical (small molecule) | [InChI]
1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16) | [InChIKey]
LMJSLTNSBFUCMU-UHFFFAOYSA-N | [SMILES]
NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl | [CAS DataBase Reference]
133-67-5(CAS DataBase Reference) | [EPA Substance Registry System]
Trichlormethiazide (133-67-5) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R42/43:May cause sensitization by inhalation and skin contact . | [Safety Statements ]
S36:Wear suitable protective clothing . | [RIDADR ]
UN2811 | [WGK Germany ]
2
| [RTECS ]
DK8925000
| [TSCA ]
TSCA listed | [HazardClass ]
6.1 | [HS Code ]
2935904000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Resp. Sens. 1
Skin Sens. 1 | [Hazardous Substances Data]
133-67-5(Hazardous Substances Data) | [Toxicity]
LD50 orally in rats: >20000 mg/kg (Goldenthal) |
| Hazard Information | Back Directory | [Chemical Properties]
Trichlormethiazide occurs as a white or practically white, crystalline powder and may have a slight characteristic odor. | [Originator]
Naqua,Schering,US,1960 | [Uses]
diuretic, antihypertensive | [Uses]
Trichlormethiazide is a diuretic and anti-hypertensive agent from the benzothiadiazide class which is used in veterinary medicine in cattle, sheep, goats, pigs and horses, at the following therapeutic regimen: a single intramuscular dose of 0.4 mg/kg bw followed by two oral doses of 0.8 mg/kg bw given 12 and 36 hours after the first administration.
Trichlormethiazide is also used in humans in the United States as a diuretic and anti-hypertensive substance but not in the European Union. The usual dose is 2 to 4 mg twice a day (i.e. approximately 0.033 to 0.066 mg/kg bw/day). | [Definition]
ChEBI: Trichlormethiazide is a benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a sulfonamide antibiotic. | [Manufacturing Process]
A mixture of 5.7 grams (0.02 mol) of 5-chloro-2,4-disulfamylaniline and 4.9
grams (0.04 mol) of dichloroacetaldehyde in 25 ml of dimethyl formamide was
heated at the boiling temperature and under reflux for 30 minutes. The
reaction mixture was thereafter poured into a mixture of ice and water to
precipitate the desired 6-chloro-7-sulfamyl-3-dichloromethyl-3,4-dihydro-
1,2,4-benzothiadiazine-1,1-dioxide as a crystalline solid melting at 250° to
270°C with decomposition. | [Therapeutic Function]
Diuretic |
|
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J & K SCIENTIFIC LTD.
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Aemon Chemical
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