163271-32-7
中文名称
5-氨基酮戊酸苄酯盐酸盐
英文名称
5-Aminolevulinic acid benzyl ester hydrochloride
CAS
163271-32-7
分子式
C12H16ClNO3
分子量
257.71
MOL 文件
163271-32-7.mol
163271-32-7 结构式
基本信息
中文别名
5-氨基酮戊酸苄酯盐酸盐 英文别名
Benzyl-ALA hydrochlorideALA BENZYL ESTER HYDROCHLORIDE
5-aminolevulinic acid benzyl ester
5-Aminolevulinic acid benzyl ester HCl
Benzyl 5-amino-4-oxopentanoate hydrochloride
AMINOLEVULINIC ACID BENZYL ESTER HYDROCHLORIDE
5-AMINOLEVULINIC ACID BENZYL ESTER HYDROCHLORIDE
DELTA-AMINOLEVULINIC ACID BENZYL ESTER HYDROCHLORIDE
5-AMINO-4-OXOPENTANOIC ACID BENZYL ESTER HYDROCHLORIDE
Pentanoic acid, 5-amino-4-oxo-, phenylmethyl ester, hydrochloride (1:1)
常见问题列表
生物活性
5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) 是一种用作光检测器的原卟啉前体。5-ALA benzyl ester hydrochloride 诱导原卟啉 IX (PPIX) 在结肠癌细胞系中的积聚。靶点
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Human Endogenous Metabolite
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体外研究
5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) (0.6-0.12 mM; 3 h) induces protoporphyrin IX (PPIX) accumulation in colon carcinoma cell lines SW480.
体内研究
Reducing the dose of 5-ALA benzyl ester hydrochloride (31 mg/kg; i.v. ; 1 hours) results in a dose-dependent reduction in tumour porphyrin levels.
| Animal Model: | Female CBA/Gy mouse (CaNT tumour model) |
| Dosage: | 31 mg/kg |
| Administration: | i.v. ; 1 hours |
| Result: | Reducing the dose of 5-ALA benzyl ester hydrochloride resulted in a dose-dependent reduction in the concentration of porphyrins accumulating in the CaNT tumour. |