27113-22-0
27113-22-0 结构式
基本信息
姜酮酚价格
姜酮酚厂家
姜酮酚作用
非洲豆蔻醇
食品级姜酮酚
姜酮酚生产厂家
食品级姜酮酚厂家
5-去氧-姜辣醇
5-去氧-6-姜酚
PARADOL
5-Paradol
6-paradol
Ccris 8519
Brn 1984119
[6]-Gingerone
6-Paradol 98%
PARADOL PARADOL
Einecs 248-228-1
物理化学性质
制备方法
53172-10-4
27113-22-0
在氮气保护下，向反应烧瓶中加入16g金属钠、3.5g无水乙酸钠和110g四氢呋喃，室温搅拌。缓慢滴加由50g烯烃中间体和200g乙醇组成的溶液，滴加过程约2小时完成。随后加热回流反应，通过薄层色谱（展开剂比例为石油醚：二氯乙烷=3：2）监测反应进程。待原料完全消失后，继续反应3.5小时。停止反应，加入10g活性炭，继续回流0.5小时。反应混合物经过滤后，减压浓缩除去溶剂。残余物用水洗涤，分层后脱水，得到淡黄色油状产物。产物纯度为98%，收率为94%。
参考文献：
[1] Patent: CN106866393, 2017, A. Location in patent: Paragraph 0045; 0046; 0047; 0048
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972, p. 3001 - 3006
常见问题列表
2. 循环系统：6-姜酮酚可以降低血压和血脂，减少动脉粥样硬化的发生，对心血管系统有保护作用。
3. 免疫系统：研究发现，6-姜酮酚可以增强机体的免疫功能，提高抗病能力，有助于预防和治疗免疫系统相关的疾病。
4. 神经系统：6-姜酮酚具有镇静、镇痛和抗抑郁作用，可以改善神经系统相关疾病的症状。
5-去氧-6-姜辣醇是有机合成中间体和医药中间体，主要用于实验室研发过程和化工医药合成过程中。
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COX-2
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Paradol ([6]-paradol) induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism.
Administration of Paradol (6-paradol) (10 mg/kg) clearly reduces the number of Iba1-positive cells 1 and 3 days after the challenge. Moreover, Paradol dramatically reduces the number of Iba1-postive cells in periischemic regions even after 3 days following M/R challenge. Paradol (6-paradol) exhibits the strongest anti-inflammatory effect of several paradol compounds in lipopolysaccharide-stimulated BV2 microglia derived from a mouse brain, including 2-, 4-, 6-, 8-, and 10-paradol. Furthermore, Paradol shows the strongest pungency of all of the known paradol analogues. Paradol also shows the highest contact time at the antiobesity site of action on the basis of the results shown for the absorption of the metabolites in this study.