283172-68-9
283172-68-9 结构式
基本信息
中文别名
化合物 T13333 英文别名
WD2000-0125476H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 1,3,4,5-tetrahydro-2-phenyl-
物理化学性质
熔点249-255 °C (decomp)
沸点600.2±44.0 °C(Predicted)
密度1.270±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)14.94±0.20(Predicted)
常见问题列表
生物活性
WD2000-012547 是一种选择性的 PARP-1 抑制剂，pKi 为 8.221。靶点
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PARP-1 8.221 (pKi) |
体外研究
Poly(ADP-ribose) polymerase-1 (PARP-1) functions as a DNA damage sensor and signaling molecule. It plays a vital role in the repair of DNA strand breaks induced by radiation and chemotherapeutic drugs; inhibitors of this enzyme have the potential to improve cancer chemotherapy or radiotherapy. WD2000-012547 (Compound 66) is a representative PARP-1 inhibitor with a pK i of 8.221.