3155-48-4
3155-48-4 结构式
基本信息
DL-醉椒素
反式-5,6-二氢-4-甲氧基-6-(2-苯基乙烯基)-2H-吡喃-2-酮
DL-KAWAIN
KAVAIN, DL-
KAWAIN
TRANS-5,6-DIHYDRO-4-METHOXY-6-(2-PHENYLETHENYL)-2H-PYRAN-2-ONE
KAVAIN, D/L-(P)
METHYSTICIN SNAP-N-SHOOT 0.1mg/mL(P)
METHYSTICIN(P)
Kavain
DL-Kawain, trans-5,6-Dihydro-4-methoxy-6-(2-phenylethenyl)-2H-pyran-2-one
Kavain，DL-Kavain
物理化学性质
常见问题列表
Two-electrode voltage clamp technique is used to characterize the functional properties of the major anxiolytic kavalactone, Kavain at human recombinant α1β2, β2γ2L, αxβ2γ2L, α1βxγ2L and α4β2δ γ-Aminobutyric acid type A receptors (GABAARs) expressed in Xenopus oocytes. Kavain positively modulates all receptors regardless of the subunit composition, but the degree of enhancement is greater at α4β2δ than at α1β2γ2L GABAARs. The modulatory effect of Kkavain is unaffected by flumazenil, indicating that Kavain does not enhance GABAARs via the classical benzodiazepine binding site. The β3N265M point mutation which has been previously shown to profoundly decrease anaesthetic sensitivity, also diminishes Kavain-mediated potentiation.