437-64-9
437-64-9 结构式
基本信息
芫花素
5,4'-二羥-7-甲氧黃酮
5,4'-DIHYDROXY-7-METHOXYFLAVONE
7-METHOXYAPIGENIN
APIGENIN-7-METHYL ETHER
GENKWANIN
7-Methylapigenin
7-O-Methylapigenin
Apigenin 7-O-Methyl Ether
Puddumetin
2-(4-Hydroxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one
物理化学性质
常见问题列表
芫花为瑞香科植物芫花Daphne genkwa Sieb.et Zucc.的干燥花蕾。分布于福建、浙江、江苏、安徽、湖北、湖南等地。芫花具有泻水逐饮、解毒杀虫的功效。主要用于治疗水肿胀满、胸腹积水、痰饮积聚、气逆喘咳、二便不利等症。外用可治疗疥癣秃疮、冻疮。临床多醋炙为醋芫花使用或生用。芫花的根皮具有“催生去胎”作用，我国民间用其引产。其叶可治疗牙疼和间日疟。芫花的成分主要有芫花素(Genkwanin)、芹菜素(Apigenin)、3′-羟基芫花素(3′-Hydroxygenkwanin)、芫根甙 (Yuankanin)、木犀草素 (Luteolin)、芫花瑞香宁 (Genkwadaphnin)、芫花酯甲 (芫花萜，Yuanhuacine)、芫花酯乙(Yuanhuadine)、芫花酯丙(Yuanhuafine)、芫花酯丁 (Yuanhuatine)、芫花酯戊 (Yuanhuapine)。挥发油有棕榈酸、油酸、亚油酸等。尚含谷甾醇、苯甲酸及刺激有毒油状物等。
芫花素还具有抗氧化、抗肿瘤、抗炎以及镇痛等多种功效, 且毒副反应少。
由2，4-甲氧基-6-羟基苯乙酮为原料与取代苯甲醛反应制得：
图1为芫花素的合成路线
有关芫花素的概述、合成方法是由Chemicalbook的侍艳编辑整理。（2016-01-13）
Cell viability analysis shows that Genkwanin does not affect the cell viability up to a concentration of 50 μM. Genkwanin inhibits the LPS-induced production of NO in a concentration-dependent manner. iNOS only expresses in the present of external stimulus. Genkwanin could not significantly affect the activity of iNOS. The effect of Genkwanin on the production of proinflammatory cytokines is examined. Genkwanin suppresses the productions of TNF-a, IL-1b and IL-6 in LPS stimulated RAW264.7 macrophages in a concentration-dependent manner. Genkwanin significantly suppresses the AP-1 signaling pathway but has little effect on the NF-kB signaling pathway. It is indicated that Genkwanin suppresses the phosphorylation of p38 and JNK in a concentration-dependent manner, but little affects ERK1/2 phosphorylation. Originally identified as an immediate early gene, MKP-1 is then found to be a dual specificity phosphatase acting as a negative regulator of ERK1/2, JNK and p38 MAPK activities, with predominant effects on the latter two. Pretreatment with Genkwanin markedly up-regulates the expression of MKP-1 without affecting MKP-1 mRNA.