480-66-0
中文名称
2,4,6-三羟基苯乙酮
英文名称
2',4',6'-Trihydroxyacetophenone monohydrate
CAS
480-66-0
EINECS 编号
207-556-5
分子式
C8H10O5
MDL 编号
MFCD00002287
分子量
186.16
MOL 文件
480-66-0.mol
更新日期
2024/04/24 11:43:04
480-66-0 结构式
基本信息
中文别名
2,4,6-三羟基苯乙酮，水合2,4,6-三羟基苯乙酮
2',4',6'-三羟基苯乙酮一水合物
2',4',6'-三羟基苯乙酮水合物
2',4',6'-三羟基苯乙酮 水合物, 98+%
英文别名
1-(2,4,6-TRIHYDROXYPHENYL)-ETHANONE2',4',6'-TRIHYDROXYACETOPHENONE
PHLOROACETOPHENONE
1-(2,4,6-trihydroxyphenyl)-ethanon
2,4,6-Trihydroxyacetophenon
2,4,6-TrihydroxyacetophenonMonohydrat
2,4,6-trihyroxyacetophenone
2-Acetyl-1,3,5-trihydroxybenzene
2-Acetylphloroglucin
Acetophenone, 2',4',6'-trihydroxy-
Acetophenone,2’,4’,6’-trihydroxy-
Acetophloroglucine
Acetylphloroglucinol
Ethanone,1-(2,4,6-trihydroxyphenyl)-
Phloracetophene
Phloracetophenone
Phloroacetophenonehydrate
2,4,6-TRIHYDROXYACETOPHENONE(PHLOROACETOPHENONE)
2,4,6-Trihydroxyaetcophenone
2,4,6-TRIHYDROXYACETOPHENONE MONOHYDRATE, PGE. WITH 10X10 MG
所属类别
化学试剂：芳香酮物理化学性质
外观性状微黄色结晶。熔点217-219℃。
熔点219-221 °C(lit.)
沸点257.07°C (rough estimate)
密度1.3037 (rough estimate)
折射率1.5090 (estimate)
储存条件Store below +30°C.
溶解度可溶于DMSO（少量）、乙醇（少量）、甲醇（少量）、水（非常少量，
酸度系数(pKa)7.76±0.23(Predicted)
形态粉末
颜色light yellow
水溶解性易溶于水。
BRN1911197
稳定性Stable under recommended storage conditions., Stable Under Recommended Storage C
LogP1.472 (est)
安全数据
警示词警告
危险性描述H303-H315-H319-H335
危险品标志Xi
危险类别码R36/37/38
安全说明S26-S36-S24/25
WGK Germany3
RTECS号AN0528000
Hazard NoteIrritant
TSCAYes
危险等级IRRITANT
海关编码29145000
常见问题列表
生物活性
Phloracetophenone (2,4,6-trihydroxyacetophenone) 是多叶姜黄 (Curcuma comosa Roxb) 中苯乙酮糖苷的糖苷配基部分，具有降低胆固醇作用，能够增强胆固醇 7α-羟化酶 (CYP7A1) 的活性；Phloracetophenone 通过 Mrp2 刺激胆汁分泌。靶点
Cholesterol 7α-hydroxylase, Mrp2
体外研究
Phloracetophenone (2,4,6-trihydroxyacetophenone) is a cholesterol-lowering agent, enhances cholesterol 7α-hydroxylase (CYP7A1) activity, and elevates CYP7A1 mRNA level.
Phloracetophenone (1, 2, and 4 μmol/min) immediately and dose-dependently increases bile acid-independent bile flow in the isolated perfused rat liver.
体内研究
Phloracetophenone (2,4,6-trihydroxyacetophenone; 125 or 250 μmol/kg, intraduodenal injection) shows choleretic activity requiring multidrug resistance protein-2 (Mrp2) in rats. Phloracetophenone (40 μmol/min) partially prevents the E2-17G induced cholestasis.