490-78-8
中文名称
2,5-二羟基苯乙酮
英文名称
2',5'-Dihydroxyacetophenone
CAS
490-78-8
EINECS 编号
207-716-4
分子式
C8H8O3
MDL 编号
MFCD00002343
分子量
152.15
MOL 文件
490-78-8.mol
更新日期
2024/04/18 11:53:07
490-78-8 结构式
基本信息
中文别名
2,5-二羟基苯乙酮2',5'-二羟基苯乙酮
2,5-二羟基乙酰苯
2,5-二羥苯乙酮
2-乙醯氫醌
2',5'-二羟基苯乙酮, 98+%
英文别名
1-(2,5-DIHYDROXYPHENYL)ETHAN-1-ONE1-(2,5-DIHYDROXYPHENYL)ETHANONE
2',5'-DIHYDROXYACETOPHENONE
2,5-DIHYDROXYACETOPHENONE
2,5-DIHYDROXYPHENYL METHYL KETONE
2-ACETYL-1,4-DIHYDROXYBENZENE
2-ACETYLHYDROQUINONE
ACETYLQUINOL
QUINACETOPHENONE
1-(2,5-dihydroxyphenyl)-ethanon
1-Acetyl-2,5-dihydroxybenzene
2,5-Dihydroxy-1-acetylbenzene
2’,5’-dihydroxy-acetophenon
Acetophenone, 2',5'-dihydroxy-
Acetylhydroquinone
2',5'-Dihydroxyacetophenone 2-Acetylhydroquinone
2,5-Dihydroxyacetophenone, 98+%
2-Acethylhydroquinone
Ethanone, 1-(2,5-dihydroxyphenyl)-
2,5-DIHYDROXYACETOPHENONE extrapure
所属类别
化学试剂：芳香酮物理化学性质
外观性状淡黄绿色针状结晶。熔点202-203℃。溶于醇，难溶于醚和苯，几乎不溶于冷水。在碱溶液中呈黄色，遇三氧化铁呈蓝色。能升华。
熔点204-206 °C(lit.)
沸点234.6°C (rough estimate)
密度1.2143 (rough estimate)
折射率1.4447 (estimate)
储存条件Store below +30°C.
溶解度dioxane: 50 mg/mL, clear
酸度系数(pKa)9.86±0.18(Predicted)
形态晶体或结晶粉末
颜色黄色至黄绿色
水溶解性insoluble
BRN637903
InChIKeyWLDWSGZHNBANIO-UHFFFAOYSA-N
LogP1.274 (est)
安全数据
警示词警告
危险性描述H315-H319-H335
危险品标志Xi
危险类别码R36/37/38
安全说明S26-S36
WGK Germany3
RTECS号AM7700000
Hazard NoteIrritant
TSCAYes
海关编码29145000
知名试剂公司产品信息
Acros Organics
2',5'-二羟基苯乙酮2',5'-Dihydroxyacetophenone, 97%(490-78-8)
Sigma Aldrich
490-78-8(sigmaaldrich)2,5-二羟基苯乙酮价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-W001174 | 2,5-二羟基苯乙酮 2,5-Dihydroxyacetophenone | 490-78-8 | 100mg | 550元 |
| 2024/01/25 | HY-W001174 | 2,5-二羟基苯乙酮 2,5-Dihydroxyacetophenone | 490-78-8 | 10mM * 1mLin DMSO | 610元 |
| 2024/01/16 | A12185 | 2',5'-二羟基苯乙酮, 98+% 2',5'-Dihydroxyacetophenone, 98+% | 490-78-8 | 5g | 312元 |
常见问题列表
生物活性
2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) 是二羟基苯乙酮异构体的混合物，用于食品调味。2',5'-Dihydroxyacetophenone 通过抑制 iNOS 的表达来显着抑制 NO 的产生。2',5'-Dihydroxyacetophenone 可通过阻断 ERK1/2 和 NF-κB 信号通路来显著地降低促炎细胞因子 TNF-α 和 IL-6 的表达水平。靶点
| Target | Value |
|
iNOS
() | |
|
ERK1/2
() | |
|
NF-κB
() | |
|
TNF-α
() | |
|
IL-6
() |
体外研究
2,5-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression and significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 via the down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. 2,5-Dihydroxyacetophenone potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells.