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59-42-7

中文名称 去氧肾上腺素碱
英文名称 Phenylephrine
CAS 59-42-7
EINECS 编号 200-424-8
分子式 C9H13NO2
MDL 编号 MFCD00044749
分子量 167.21
MOL 文件 59-42-7.mol
更新日期 2024/04/17 15:50:17
59-42-7 结构式 59-42-7 结构式

基本信息

中文别名
3-羟基-alpha-((甲基氨基)甲基)-苄醇
去氧肾上腺素碱
去羟肾上腺素
去氧肾上腺
新交感酚
新辛内井林
英文别名
3-(1-HYDROXY-2-METHYLAMINO-ETHYL)PHENOL
L-PHENYLEPHRINE
(-)-PHENYLEPHRINE
PHENYLEPHRINE BASE
(-)-m-Hydroxy-alpha-(methylaminomethyl)benzyl alcohol
(-)-m-hydroxy-alpha-(methylaminomethyl)benzylalcohol
(-)-m-oxedrine
(R)-3-Hydroxy-alpha-[(methylamino)methyl]benzenemethanol hydrochloride
(r)-benzenemethano
(r)-phenylephrine
Adrianol
Ak-dilate
Ak-nefrin
Alcon efrin
Benzyl alcohol, m-hydroxy-alpha-((methylamino)methyl)-, (-)-
Biomydrin
component of Cerose dm
component of Comhist
component of Cyclomydril
component of Decongestant
所属类别
分析化学:药典标准品和杂质标准品

物理化学性质

熔点171°C
沸点295.79°C (rough estimate)
密度1.1222 (rough estimate)
折射率-55.5 ° (C=5, 1mol/L HCl)
储存条件-20°C Freezer, Under inert atmosphere
溶解度Slightly soluble in water, sparingly soluble in methanol, slightly soluble in ethanol (96 per cent). It dissolves in dilute mineral acids and in dilute solutions of alkali hydroxides.
酸度系数(pKa)pKa 8.9 (Uncertain)
形态neat
颜色白色至灰白色

安全数据

危险性符号(GHS)
GHS05,GHS07
警示词危险
危险性描述H302-H315-H318-H335
危险品标志Xn
危险类别码R22-R36/37/38
安全说明S26-S36-S45
RTECS号DO7175000
海关编码2922.19.7000
毒性LD50 oral in rat: 350mg/kg

应用领域

用途一
拟肾上腺素药物,用于外科手术延长局部麻醉时间、鼻粘膜充血、急性低血压、感染中毒性及过敏性休克等症

知名试剂公司产品信息

去氧肾上腺素碱价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/01/25HY-B0769去氧肾上腺素碱
Phenylephrine
59-42-7500mg500元
2024/01/25HY-B0769去氧肾上腺素碱
Phenylephrine
59-42-710mM * 1mLin DMSO550元
2024/01/16P0395L-苯肾上腺素
L-Phenylephrine
59-42-75G720元

常见问题列表

生物活性
(R)-(-)-Phenylephrine是选择性的α1-肾上腺素受体激动剂,主要用作减充血剂。
体外研究

(R)-(-)-Phenylephrine is a selective α 1 -adrenoceptor agonist with pK i values of 5.86, 4.87 and 4.70 for α 1D , α 1B and α 1A receptors respectively. Phenylephrine promotes cardiac fibroblast proliferation. Phenylephrine activates CaN and evokes NFAT3 nuclear translocation. It suggests that the Ca( 2+ )/CaN/NFAT pathway mediates phenylephrine -induced cardiac fibroblast proliferation, and this pathway might be a possible therapeutic target in cardiac fibrosis.

体内研究

Perfusion of hearts with 100 μM phenylephrine causes a rapid (maximal at 10 min) 12-fold activation of two p38-MAPK isoforms. α 1 -adrenoceptor agonists such as phenylephrine increase the contractility of the heart. Phenylephrine also activates SAPKs/JNKs in neonatal ventricular myocytes. Phenylephrine could increase the alveolar fluid clearance in high tidal volume-ventilated rats and accelerate the absorption of pulmonary edema.

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