6398-98-7
中文名称
阿莫地喹盐酸盐
英文名称
Amodiaquin dihydrochloride dihydrate
CAS
6398-98-7
EINECS 编号
200-706-0
分子式
C20H24Cl3N3O
MDL 编号
MFCD00078857
分子量
428.78
MOL 文件
6398-98-7.mol
更新日期
2024/03/27 11:57:34
6398-98-7 结构式
基本信息
中文别名
7-氯-4-(3'-二乙基氨基甲基-4'-羟基苯胺基)喹啉二盐酸盐阿莫地喹盐酸盐
盐酸阿莫地喹
阿莫地喹
阿莫地喹盐酸盐
英文别名
4-[(7-CHLORO-4-QUINOLINYL)AMINO]-2-[(DIETHYLAMINO)METHYL]PHENOL DIHYDROCHLORIDE4-([7-chloro-4-quinolinyl]amino)-2-([diethylamino]methyl)phenol dihydrochloride dihydrate
4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol dihydrochloride
7-chloro-4-(3'-diethylaminomethyl-4'-hydroxyanilino)quinoline dihydrochloride
acrichin dihydrochloride
AMODIAQUIN DIHYDROCHLORIDE
amodiaquin dihydrochloride dihydrate
AMODIAQUINE DIHYDROCHLORIDE
AMODIAQUINE HCL
AMODIAQUINE HYDROCHLORIDE
AMODIAQUIN HYDROCHLORIDE
Amodiaquine hydrochloride USP24
AMODIAQUINE 2HCL DIHYDRATE
AMODIAQUINE DIHYDROCHLORIDE 2-HYDRATE
AMODIAQUIN DIHYDROCHLORIDE DIHYDATE
物理化学性质
RTECS号GO7300100
储存条件Inert atmosphere,Room Temperature
溶解度溶于DMSO或甲醇
形态neat
最大波长(λmax)342nm(MeOH)(lit.)
Merck14,572
阿莫地喹盐酸盐价格(试剂级)
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/01/25 | HY-B1322B | 阿莫地喹盐酸盐 Amodiaquine dihydrochloride | 6398-98-7 | 100mg | 500元 |
2024/01/25 | HY-B1322B | 阿莫地喹盐酸盐 Amodiaquine dihydrochloride | 6398-98-7 | 10mM * 1mLin DMSO | 550元 |
2024/01/16 | J64326 | 4-(7-氯-4-喹啉基氨基)-2-(二乙基氨基甲基)苯酚 二盐酸盐 二水合物,98% 4-(7-Chloro-4-quinolinylamino)-2-(diethylaminomethyl)phenol dihydrochloride dihydrate, 98% | 6398-98-7 | 5g | 405元 |
常见问题列表
生物活性
Amodiaquine在人红细胞中是一种有效的、非竞争性的组胺N-甲基转移酶抑制剂,其Ki值为18.6 nM。它也被用作抗疟疾药和消炎药。靶点
Target | Value |
histamine N-methyl transferase
(Cell-free assay) | 18.6 nM(Ki) |
体外研究
Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH
+
neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.
RT-PCR
Cell Line: | Primary microglia |
Concentration: | 10 µM, 15 µM, 20 µM |
Incubation Time: | 4 hours |
Result: | Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner. |
体内研究
在狗的体内实验中,小剂量的amodiaquine显著地增强了组胺对胃液分泌的作用。对 P. acnes-primed和LPS诱导的肝炎小鼠中,处理以amodiaquine,能有效阻止严重肝损伤和高致死性,增强了组胺的升高而不升高tele-methylhistamine (t-MeHA)。