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6398-98-7

中文名称 阿莫地喹盐酸盐
英文名称 Amodiaquin dihydrochloride dihydrate
CAS 6398-98-7
EINECS 编号 200-706-0
分子式 C20H24Cl3N3O
MDL 编号 MFCD00078857
分子量 428.78
MOL 文件 6398-98-7.mol
更新日期 2024/03/27 11:57:34
6398-98-7 结构式 6398-98-7 结构式

基本信息

中文别名
7-氯-4-(3'-二乙基氨基甲基-4'-羟基苯胺基)喹啉二盐酸盐
阿莫地喹盐酸盐
盐酸阿莫地喹
阿莫地喹
阿莫地喹盐酸盐
英文别名
4-[(7-CHLORO-4-QUINOLINYL)AMINO]-2-[(DIETHYLAMINO)METHYL]PHENOL DIHYDROCHLORIDE
4-([7-chloro-4-quinolinyl]amino)-2-([diethylamino]methyl)phenol dihydrochloride dihydrate
4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol dihydrochloride
7-chloro-4-(3'-diethylaminomethyl-4'-hydroxyanilino)quinoline dihydrochloride
acrichin dihydrochloride
AMODIAQUIN DIHYDROCHLORIDE
amodiaquin dihydrochloride dihydrate
AMODIAQUINE DIHYDROCHLORIDE
AMODIAQUINE HCL
AMODIAQUINE HYDROCHLORIDE
AMODIAQUIN HYDROCHLORIDE
Amodiaquine hydrochloride USP24
AMODIAQUINE 2HCL DIHYDRATE
AMODIAQUINE DIHYDROCHLORIDE 2-HYDRATE
AMODIAQUIN DIHYDROCHLORIDE DIHYDATE

物理化学性质

RTECS号GO7300100
储存条件Inert atmosphere,Room Temperature
溶解度溶于DMSO或甲醇
形态neat
最大波长(λmax)342nm(MeOH)(lit.)
Merck14,572

安全数据

危险性符号(GHS)
GHS07
警示词警告
危险性描述H315-H319-H335
WGK Germany3
海关编码2933492250

应用领域

用途一
用作抗疟药

知名试剂公司产品信息

阿莫地喹盐酸盐价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/01/25HY-B1322B阿莫地喹盐酸盐
Amodiaquine dihydrochloride
6398-98-7100mg500元
2024/01/25HY-B1322B阿莫地喹盐酸盐
Amodiaquine dihydrochloride
6398-98-710mM * 1mLin DMSO550元
2024/01/16J643264-(7-氯-4-喹啉基氨基)-2-(二乙基氨基甲基)苯酚 二盐酸盐 二水合物,98%
4-(7-Chloro-4-quinolinylamino)-2-(diethylaminomethyl)phenol dihydrochloride dihydrate, 98%
6398-98-75g405元

常见问题列表

生物活性
Amodiaquine在人红细胞中是一种有效的、非竞争性的组胺N-甲基转移酶抑制剂,其Ki值为18.6 nM。它也被用作抗疟疾药和消炎药。
靶点
TargetValue
histamine N-methyl transferase
(Cell-free assay)
18.6 nM(Ki)
体外研究

Amodiaquine (10-20 μM; 4 hours) treatment suppresses LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
Amodiaquine (5 μM; 24 hours) significantly inhibits neurotoxin (6-OHDA-induced cell death in primary dopamine cells as examined by the number of TH + neurons and dopamine uptake. The neuroprotective effect of Amodiaquine is also observed in rat PC12 cells.

RT-PCR

Cell Line: Primary microglia
Concentration: 10 µM, 15 µM, 20 µM
Incubation Time: 4 hours
Result: Suppressed LPS-induced expression of proinflammatory cytokines (IL-1β, interleukin-6, TNF-α and iNOS) in a dose-dependent manner.
体内研究
在狗的体内实验中,小剂量的amodiaquine显著地增强了组胺对胃液分泌的作用。对 P. acnes-primed和LPS诱导的肝炎小鼠中,处理以amodiaquine,能有效阻止严重肝损伤和高致死性,增强了组胺的升高而不升高tele-methylhistamine (t-MeHA)。
"6398-98-7" 相关产品信息
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