| Identification | More | [Name]
Amodiaquin dihydrochloride dihydrate | [CAS]
6398-98-7 | [Synonyms]
4-[(7-CHLORO-4-QUINOLINYL)AMINO]-2-[(DIETHYLAMINO)METHYL]PHENOL DIHYDROCHLORIDE
4-([7-chloro-4-quinolinyl]amino)-2-([diethylamino]methyl)phenol dihydrochloride dihydrate
4-[(7-chloroquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol dihydrochloride
7-chloro-4-(3'-diethylaminomethyl-4'-hydroxyanilino)quinoline dihydrochloride
acrichin dihydrochloride
AMODIAQUIN DIHYDROCHLORIDE
amodiaquin dihydrochloride dihydrate
AMODIAQUINE DIHYDROCHLORIDE
AMODIAQUINE HCL
AMODIAQUINE HYDROCHLORIDE
AMODIAQUIN HYDROCHLORIDE
Amodiaquine hydrochloride USP24
AMODIAQUINE 2HCL DIHYDRATE
AMODIAQUINE DIHYDROCHLORIDE 2-HYDRATE
AMODIAQUIN DIHYDROCHLORIDE DIHYDATE | [EINECS(EC#)]
200-706-0 | [Molecular Formula]
C20H24Cl3N3O | [MDL Number]
MFCD00078857 | [Molecular Weight]
428.78 | [MOL File]
6398-98-7.mol |
| Chemical Properties | Back Directory | [RTECS ]
GO7300100 | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Soluble in DMSO or methanol | [form ]
neat | [color ]
White to Yellow to Orange | [λmax]
342nm(MeOH)(lit.) | [Merck ]
14,572 | [Stability:]
Hygroscopic | [Major Application]
forensics and toxicology
pharmaceutical (small molecule) | [InChI]
InChI=1S/C20H22ClN3O.ClH.H2O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19;;/h5-12,25H,3-4,13H2,1-2H3,(H,22,23);1H;1H2 | [InChIKey]
AOFIMJMWPZOPAJ-UHFFFAOYSA-N | [SMILES]
N(C1C=CC(O)=C(CN(CC)CC)C=1)C1=CC=NC2=CC(Cl)=CC=C12.Cl.O | [CAS DataBase Reference]
6398-98-7(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Light yellow powder | [Uses]
An anti-malarial quinoline derivative that acts as an histamine N-methyltransferase inhibitor | [Uses]
antimalarial | [Brand name]
Camoquin (Parke-Davis). | [Biological Activity]
Amodiaquine is a potent, non-competitive inhibitor of histamine N-methyl transferase with estimated Ki of 18.6 nM. It is also used as an antimalarial and anti-inflammatory agent. | [in vivo]
In vivo administration of a small dose amodiaquine dramatically enhanced the effect of histamine on the gastric secretion in dogs. Amodiaquine prevents severe hepatic injury and high lethality in P. acnes-primed and LPS-induced hepatitis mice. Its treatment enhances the elevation of histamine in the liver of P. acnes-primed and LPS-induced hepatitis mice without accompanying tele-methyl histamine elevation. | [IC 50]
Plasmodium; Nurr1/NR4A2 |
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