68278-23-9
基本信息
盐酸依氟乌氨酸
盐酸恩氟沙星
盐酸依氟鸟氨酸无水物
2-(DIFLUOROMETHYL)-ORNITHINE HYDROCHLORIDE
DFMO
DFMO HCL
DFMO HYDROCHLORIDE
DL-ALPHA-DIFLUOROMETHYLORNITHINE HYDROCHLORIDE
EFLORNITHINE HCL
EFLORNITHINE HYDROCHLORIDE
RMI-71782
RMI-71782 HYDROCHLORIDE
2-(difluoromethyl)-dl-ornithinehydrochloridehydrate
alpha-difluoromethylornithinehydrochloridehydrate
dl-ornithine,2-(difluoromethyl)-,monohydrochloride,hydrate
eflornithinehydrochloridehydrate
DL-alpha-Difluoromethylonithine
EflornitineHCl
Eflornitinehydrochloride
2-(Difluoromethyl)-DL-Ornithine hydrochloride
物理化学性质
常见问题列表
依氟鸟氨酸:该分子比美拉胂醇的毒性小,于1990年获得注册。它仅对布氏冈比亚锥虫有效。疗程复杂,而且难以施用。尤其是在昏睡病高发的非洲农村地区,医疗设备和医务人员的紧缺让这种治疗方案的实施面临重重阻碍。
2009年,包括非营利性药物研发组织DNDi(被忽视疾病药物倡议)、无国界医生组织等在内的国际合作组织开发了一种称为NECT的联合疗法,由硝呋替莫和依氟鸟氨酸联合使用,比单用依氟鸟氨酸简便,安全性和治疗效果也大大改善。它通过减少治疗的持续时间和静脉输液的次数,简化了依氟鸟氨酸的使用,但不幸的是,没有研究它对布氏罗得西亚锥虫是否有效。硝呋替莫被注册用于治疗美洲锥虫病,但未注册用于治疗非洲人类锥虫病。尽管如此,在临床试用提供了安全性和有效性数据之后,该药与依氟鸟氨酸的联合使用已被列入世卫组织基本药物清单,而且目前建议作为冈比亚型感染的一线治疗。世卫组织为此目的免费为地区性流行国家提供这两种药物和载有用法所需的所有材料的材料包。
Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.